Department of Cardiology, The 8th Medical Center of Chinese PLA General Hospital, Beijing, People's Republic of China.
These authors contributed equally to this paper.
Angiology. 2021 Oct;72(9):878-888. doi: 10.1177/00033197211004412. Epub 2021 Apr 15.
This study aimed to determine the efficacy of alprostadil in preventing contrast-induced nephropathy (CIN). Eligible studies were searched using the keywords through the databases of PubMed, Cochrane, Embase, China Biological Medicine Database, China National Knowledge Infrastructure, and Vanfun. Quality evaluation of the included studies was conducted according to international evidence evaluation and recommended Grades of Recommendations Assessment, Development, and Evaluation standards. We included 29 studies with 5623 patients. Compared with hydration, 10 µg/d alprostadil or 20 µg/d alprostadil plus hydration significantly decreased the incidence of CIN. Compared with hydration, alprostadil plus hydration significantly reduced serum creatinine and blood urea nitrogen at 24, 48, and 72 hours and 7 days after coronary angiography (CAG). Alprostadil (20 µg/d) plus hydration significantly decreased serum cystatin versus hydration at 24, 48, and 72 hours after CAG. Compared with hydration, alprostadil plus hydration significantly increased glomerular filtration rate at 24 and 72 hours after CAG. Alprostadil plus hydration significantly decreased neutrophil gelatinase-associated lipocalin levels compared to hydration at 24, 48, and 72 hours after CAG. Alprostadil plus hydration significantly decreased urine macroglobulin versus hydration at 24 and 48 hours after CAG.
本研究旨在确定前列地尔预防对比剂诱导肾病（CIN）的疗效。通过使用关键词在 PubMed、Cochrane、Embase、中国生物医学文献数据库、中国国家知识基础设施和万仿数据库中搜索符合条件的研究。根据国际证据评估和推荐的建议评估、制定和评估标准对纳入研究进行质量评估。我们纳入了 29 项研究，共 5623 名患者。与水化相比，10 µg/d 前列地尔或 20 µg/d 前列地尔加水化显著降低 CIN 的发生率。与水化相比，前列地尔加水化在冠状动脉造影（CAG）后 24、48 和 72 小时和 7 天显著降低血清肌酐和血尿素氮。与水化相比，CAG 后 24、48 和 72 小时，前列地尔（20 µg/d）加水化显著降低血清胱抑素。与水化相比，前列地尔加水化在 CAG 后 24 和 72 小时显著增加肾小球滤过率。与水化相比，前列地尔加水化在 CAG 后 24、48 和 72 小时显著降低中性粒细胞明胶酶相关脂质运载蛋白水平。与水化相比，前列地尔加水化在 CAG 后 24 和 48 小时显著降低尿巨球蛋白。
