精神分裂症的转甲基化假说：蛋氨酸与烟酸
Transmethylation hypothesis of schizophrenia: methionine and nicotinic acid.
作者信息
Nestoros J N, Ban T A, Lehmann H E
出版信息
Int Pharmacopsychiatry. 1977;12(4):215-46. doi: 10.1159/000468311.
PMID:338534
Abstract
The transmethylation hypothesis of schizophrenia was reviewed with considerations that large doses of methionine when combined with a monoamine oxidase inhibitor lead to exacerbation of psychotic symptoms in a significant percentage of chronic schizophrenic patients. It was noted that nicotinic acid in the dosage of 3,000 mg/day can neither prevent nor counteract the psychopathology thus induced.
摘要
对精神分裂症的转甲基化假说进行了综述，考虑到在相当比例的慢性精神分裂症患者中，大剂量蛋氨酸与单胺氧化酶抑制剂合用时会导致精神病症状加重。值得注意的是，每天3000毫克剂量的烟酸既不能预防也不能对抗由此诱发的精神病理学症状。
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