Nestoros J N, Ban T A, Lehmann H E
Int Pharmacopsychiatry. 1977;12(4):215-46. doi: 10.1159/000468311.
The transmethylation hypothesis of schizophrenia was reviewed with considerations that large doses of methionine when combined with a monoamine oxidase inhibitor lead to exacerbation of psychotic symptoms in a significant percentage of chronic schizophrenic patients. It was noted that nicotinic acid in the dosage of 3,000 mg/day can neither prevent nor counteract the psychopathology thus induced.
对精神分裂症的转甲基化假说进行了综述，考虑到在相当比例的慢性精神分裂症患者中，大剂量蛋氨酸与单胺氧化酶抑制剂合用时会导致精神病症状加重。值得注意的是，每天3000毫克剂量的烟酸既不能预防也不能对抗由此诱发的精神病理学症状。
