Graduate School, Gansu University of Chinese Medicine, Lanzhou city, 730000, China.
Departmentof Pediatrics, the Fifth People's Hospital of Chengdu, Chengdu city, 611130, China.
BMC Nephrol. 2021 Apr 14;22(1):130. doi: 10.1186/s12882-021-02350-w.
This study aimed to investigate the expression characteristics of ANGPTL8 in patients with primary nephrotic syndrome and its possible correlation with hyperlipidemia and proteinuria.
ANGPTL8 levels were determined using an enzyme-linked immunosorbent assay in 133 subjects with PNS and 60 healthy controls.
Compared with healthy controls, subjects with primary nephrotic syndrome had higher levels of serum and urine ANGPTL8 (P < 0.001). In primary nephrotic syndrome patients, serum ANGPTL8 was positively correlated with cholesterol (r = 0.209, P < 0.05) and triglycerides (r = 0.412, P < 0.001), while there was no correlation with 24 hUTP. Urine ANGPTL8 was positively correlated with high-density lipoprotein cholesterol (r = 0.181, P < 0.05) and was significantly negatively correlated with creatinine (r = - 0.323, P < 0.001), eGFR (r = - 0, P < 0.001) and 24 hUTP (r = - 0.268, P = 0.002). Interestingly, the urine ANGPTL8 concentrations in membranous nephropathy and mesangial proliferative glomerulonephritis pathological types were different.
Serum and urine ANGPTL8 levels in primary nephrotic syndrome patients were correlated with blood lipid levels and proteinuria, respectively, suggesting that ANGPTL8 may play a role in the development of primary nephrotic syndrome hyperlipidemia and proteinuria.
本研究旨在探讨原发性肾病综合征患者中 ANGPTL8 的表达特征及其与高血脂和蛋白尿的可能相关性。
采用酶联免疫吸附法检测 133 例原发性肾病综合征患者和 60 例健康对照者的 ANGPTL8 水平。
与健康对照组相比，原发性肾病综合征患者血清和尿液中的 ANGPTL8 水平均升高（P<0.001）。在原发性肾病综合征患者中，血清 ANGPTL8 与胆固醇（r=0.209，P<0.05）和甘油三酯（r=0.412，P<0.001）呈正相关，而与 24 hUTP 无相关性。尿液 ANGPTL8 与高密度脂蛋白胆固醇呈正相关（r=0.181，P<0.05），与肌酐（r=-0.323，P<0.001）、eGFR（r=-0，P<0.001）和 24 hUTP（r=-0.268，P=0.002）呈显著负相关。有趣的是，膜性肾病和系膜增生性肾小球肾炎病理类型患者的尿液 ANGPTL8 浓度存在差异。
原发性肾病综合征患者血清和尿液中 ANGPTL8 水平分别与血脂水平和蛋白尿相关，提示 ANGPTL8 可能在原发性肾病综合征高血脂和蛋白尿的发生发展中发挥作用。
