Synthesis of no-carrier-added [Pt]cisplatin from a cyclotron produced PtCl complex.

We developed a novel method for production of no-carrier-added (n.c.a.) [Pt]PtCl from an Ir target material, and then synthesized n.c.a. [*Pt]cis-[PtCl(NH)] ([*Pt]cisplatin) from [*Pt]PtCl. [*Pt]PtCl was prepared as a synthetic precursor of n.c.a. *Pt complex by a combination of resin extraction and anion-exchange chromatography after the selective reduction of IrCl with ascorbic acid. The ligand-substitution reaction of Cl with NH was promoted by treating n.c.a. [*Pt]PtCl with excess NH and heating the reaction mixture, and n.c.a. [*Pt]cisplatin was successfully produced without employing precipitation routes. After this treatment, [*Pt]cisplatin was isolated through preparative HPLC with a radiochemical purity of 99 + % at the end of synthesis (EOS).