Whitington P F, Whitington G L
Department of Pediatrics, University of Chicago Pritzker School of Medicine, Illinois 60637.
J Pediatr Gastroenterol Nutr. 1988 May-Jun;7(3):379-85. doi: 10.1097/00005176-198805000-00011.
Eosinophilic gastroenteropathy (EG) is an uncommon, idiopathic disease in children that is characterized by eosinophilic inflammation of the intestine. Over a 7-year period 17 infants and children with EG were evaluated; the retrospective review of their clinical data constitutes the basis of this report. A scale developed for grading the degree of mucosal eosinophilia was used in the evaluation of the intestinal histopathology; all patients had eosinophilic infiltration that was far more severe than that seen in other intestinal disorders of childhood. Peripheral eosinophilia was observed in 12 patients. However, two more had evidence of rapid turnover of eosinophils with significantly increased numbers of precursors in bone marrow and intense intestinal infiltration. Serum IgE correlated with the severity of the disease; extreme elevations were associated with chronic severe illness similar to that commonly reported in adults. Evidence of viral infection in two patients and dietary responsiveness in two infants bring to question the specificity of diagnosis on histology alone. Treatment with oral cromolyn sodium and/or prednisone was effective, but some patients have remained dependent upon therapy.
嗜酸性粒细胞性胃肠病（EG）是一种儿童罕见的特发性疾病，其特征为肠道嗜酸性粒细胞炎症。在7年期间，对17例患有EG的婴幼儿和儿童进行了评估；对他们临床数据的回顾性分析构成了本报告的基础。在评估肠道组织病理学时使用了一种用于对黏膜嗜酸性粒细胞增多程度进行分级的量表；所有患者的嗜酸性粒细胞浸润都比儿童期其他肠道疾病所见严重得多。12例患者观察到外周血嗜酸性粒细胞增多。然而，另有2例有嗜酸性粒细胞快速更新的证据，骨髓中前体细胞数量显著增加且肠道浸润强烈。血清IgE与疾病严重程度相关；极度升高与成人中常见的慢性重症疾病相关。2例患者有病毒感染证据，2例婴儿有饮食反应性，这使得仅靠组织学诊断的特异性受到质疑。口服色甘酸钠和/或泼尼松治疗有效，但一些患者仍依赖治疗。
