Is the Failing Heart Starved of Mitochondrial Calcium?
作者信息
Garbincius Joanne F, Elrod John W
机构信息
Center for Translational Medicine, Lewis Katz School of Medicine at Temple University, Philadelphia, PA.
出版信息
Circ Res. 2021 Apr 16;128(8):1205-1207. doi: 10.1161/CIRCRESAHA.121.319030. Epub 2021 Apr 15.
Abstract
摘要
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本文引用的文献
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MCU Overexpression Rescues Inotropy and Reverses Heart Failure by Reducing SR Ca Leak.MCU 过表达通过减少 SR Ca 渗漏来挽救心肌收缩力并逆转心力衰竭。
Circ Res. 2021 Apr 16;128(8):1191-1204. doi: 10.1161/CIRCRESAHA.120.318562. Epub 2021 Feb 1.
2
Coupled transmembrane mechanisms control MCU-mediated mitochondrial Ca uptake.偶联跨膜机制控制 MCU 介导的线粒体钙摄取。
Proc Natl Acad Sci U S A. 2020 Sep 1;117(35):21731-21739. doi: 10.1073/pnas.2005976117. Epub 2020 Aug 14.
3
The debate continues - What is the role of MCU and mitochondrial calcium uptake in the heart?这场争论仍在继续——MCU 和线粒体钙摄取在心脏中的作用是什么？
J Mol Cell Cardiol. 2020 Jun;143:163-174. doi: 10.1016/j.yjmcc.2020.04.029. Epub 2020 Apr 27.
4
Calcium Signaling and Reactive Oxygen Species in Mitochondria.钙信号与线粒体中的活性氧物种。
Circ Res. 2018 May 11;122(10):1460-1478. doi: 10.1161/CIRCRESAHA.118.310082.
5
Mitochondrial calcium overload is a key determinant in heart failure.线粒体钙超载是心力衰竭的关键决定因素。
Proc Natl Acad Sci U S A. 2015 Sep 8;112(36):11389-94. doi: 10.1073/pnas.1513047112. Epub 2015 Jul 27.
6
Inhibition of MCU forces extramitochondrial adaptations governing physiological and pathological stress responses in heart.抑制线粒体钙单向转运体可促使线粒体外适应性变化，从而调控心脏的生理和病理应激反应。
Proc Natl Acad Sci U S A. 2015 Jul 21;112(29):9129-34. doi: 10.1073/pnas.1504705112. Epub 2015 Jul 7.
7
The Mitochondrial Calcium Uniporter Selectively Matches Metabolic Output to Acute Contractile Stress in the Heart.线粒体钙单向转运体使心脏代谢输出与急性收缩应激选择性匹配。
Cell Rep. 2015 Jul 7;12(1):15-22. doi: 10.1016/j.celrep.2015.06.002. Epub 2015 Jun 25.
8
The Mitochondrial Calcium Uniporter Matches Energetic Supply with Cardiac Workload during Stress and Modulates Permeability Transition.线粒体钙单向转运体在应激期间使能量供应与心脏工作负荷相匹配并调节通透性转换。
Cell Rep. 2015 Jul 7;12(1):23-34. doi: 10.1016/j.celrep.2015.06.017. Epub 2015 Jun 25.
9
Assessment of cardiac function in mice lacking the mitochondrial calcium uniporter.对缺乏线粒体钙单向转运体的小鼠心脏功能的评估。
J Mol Cell Cardiol. 2015 Aug;85:178-82. doi: 10.1016/j.yjmcc.2015.05.022. Epub 2015 Jun 6.
10
The mitochondrial uniporter controls fight or flight heart rate increases.线粒体单向转运体控制“战斗或逃跑”反应时的心率增加。
Nat Commun. 2015 Jan 20;6:6081. doi: 10.1038/ncomms7081.
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