Hanna B, Sakiniene E, Gjertsson I, Pullerits R, Jin T
Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Department of Rheumatology, Sahlgrenska University Hospital, Gothenburg, Sweden.
Scand J Rheumatol. 2021 Sep;50(5):398-401. doi: 10.1080/03009742.2021.1882558. Epub 2021 Apr 15.
: To study the relationship between different disease-related variables and bone mineral density (BMD) in patients with idiopathic inflammatory myopathies (IIMs).: Demographic and clinical data were retrospectively collected from the medical records of all patients diagnosed with IIMs during 2003-2018 in the Rheumatology Department, Sahlgrenska University Hospital, Gothenburg, Sweden. BMD measurements by dual-energy X-ray absorptiometry (DXA) were compared among three patient groups categorized according to the time when DXA was performed in relation to the diagnosis: during the first month, 2-6 months, and 7-24 months after diagnosis.: In total, 48 patients were included in the study. BMD correlated positively with body mass index and the presence of myositis-specific autoantibodies. As expected, age and diseases duration had negative associations with BMD. Importantly, osteopenia and osteoporosis were significantly more common in patients who underwent DXA at later time-points of the disease than in those who underwent DXA during the first month after diagnosis.: Reduced BMD is common in patients with IIMs. The development of osteopenia/osteoporosis starts in the early phase of myositis (within 6 months), and immediate osteoporosis prophylaxis at diagnosis is necessary.
研究特发性炎性肌病（IIMs）患者中不同疾病相关变量与骨密度（BMD）之间的关系。
从瑞典哥德堡萨尔格伦斯卡大学医院风湿科2003年至2018年期间诊断为IIMs的所有患者的病历中回顾性收集人口统计学和临床数据。根据双能X线吸收法（DXA）检查相对于诊断的时间，将患者分为三组，比较三组患者的骨密度测量结果：诊断后第一个月内、2 - 6个月以及7 - 24个月。
该研究共纳入48例患者。骨密度与体重指数和肌炎特异性自身抗体的存在呈正相关。正如预期的那样，年龄和病程与骨密度呈负相关。重要的是，与诊断后第一个月内接受DXA检查的患者相比，在疾病后期接受DXA检查的患者中骨质减少和骨质疏松明显更为常见。
IIMs患者中骨密度降低很常见。骨质减少/骨质疏松在肌炎早期（6个月内）就开始出现，诊断时立即进行骨质疏松预防是必要的。
