Ramanathan J, Sibai B M, Duggirala V, Maduska A L
Department of Anesthesiology, College of Medicine, University of Tennessee, Memphis 38163.
J Reprod Med. 1988 May;33(5):432-5.
Pulmonary function was studied in ten preeclamptic women in labor receiving continuous infusions of MgSO4 (group I) and six normotensive, healthy parturients in labor (group II). In group I, the forced vital capacity (FVC), forced expiratory volume in one second (FEV1) and maximum voluntary ventilation (MVV) were measured prior to, two hours after and six hours after the start of infusions. The mean FVC decreased from a baseline value of 3.05 +/- 0.41 to 2.67 +/- 0.50 L (P less than .005) at two hours and to 2.71 +/- 0.42 L (P less than .005) at six hours; the mean FEV1 decreased from a control value of 2.50 +/- 0.41 to 2.25 +/- 0.45 L at two hours (P less than .01) and to 2.25 +/- 0.37 L at six hours (P less than .01). The mean MVV decreased from a baseline value of 93.75 +/- 15.6 to 84.4 +/- 17.1 L at two hours (P less than .01) and 83.75 +/- 13.5 L at six hours (P less than .02). There were no significant differences between the two- and six-hour values. There was no change in the percentage of FEV1: FVC at any time during the measurement. The mean serum magnesium level was 3.66 +/- 0.44 mg/dL. In the control group (group II), the FVC, FEV1 and MVV values were within normal limits, and there were no significant changes from baseline measurements at two and six hours. The results indicate a decrease in pulmonary function in preeclamptic patients in labor receiving MgSO4 infusions.
对10名接受硫酸镁持续静脉输注的先兆子痫产妇（I组）和6名血压正常的健康产妇（II组）进行了肺功能研究。在I组中，于输注开始前、开始后2小时和6小时测量用力肺活量（FVC）、一秒用力呼气量（FEV1）和最大自主通气量（MVV）。平均FVC在2小时时从基线值3.05±0.41降至2.67±0.50 L（P＜0.005），在6小时时降至2.71±0.42 L（P＜0.005）；平均FEV1在2小时时从对照值2.50±0.41降至2.25±0.45 L（P＜0.01），在6小时时降至2.25±0.37 L（P＜0.01）。平均MVV在2小时时从基线值93.75±15.6降至84.4±17.1 L（P＜0.01），在6小时时降至83.75±13.5 L（P＜0.02）。2小时和6小时的值之间无显著差异。在测量期间的任何时间，FEV1:FVC百分比均无变化。血清镁平均水平为3.66±0.44 mg/dL。在对照组（II组）中，FVC、FEV1和MVV值均在正常范围内，在2小时和6小时时与基线测量值相比无显著变化。结果表明，接受硫酸镁输注的分娩期先兆子痫患者肺功能下降。
