• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

N6-[2-(3,5-dimethoxyphenyl)-2-(2-methylphenyl)ethyl]adenosine and its uronamide derivatives. Novel adenosine agonists with both high affinity and high selectivity for the adenosine A2 receptor.

作者信息

Bridges A J, Bruns R F, Ortwine D F, Priebe S R, Szotek D L, Trivedi B K

机构信息

Parke-Davis Pharmaceutical Research Division, Warner-Lambert Company, Ann Arbor, Michigan 48105.

出版信息

J Med Chem. 1988 Jul;31(7):1282-5. doi: 10.1021/jm00402a004.

DOI:10.1021/jm00402a004
PMID:3385722
Abstract
摘要

相似文献

1
N6-[2-(3,5-dimethoxyphenyl)-2-(2-methylphenyl)ethyl]adenosine and its uronamide derivatives. Novel adenosine agonists with both high affinity and high selectivity for the adenosine A2 receptor.
J Med Chem. 1988 Jul;31(7):1282-5. doi: 10.1021/jm00402a004.
2
C2,N6-disubstituted adenosines: synthesis and structure-activity relationships.C2，N6-二取代腺苷：合成及构效关系
J Med Chem. 1989 Aug;32(8):1667-73. doi: 10.1021/jm00128a002.
3
4-Amino[1,2,4]triazolo[4,3-a]quinoxalines. A novel class of potent adenosine receptor antagonists and potential rapid-onset antidepressants.
J Med Chem. 1990 Aug;33(8):2240-54. doi: 10.1021/jm00170a031.
4
7-Deaza-2-phenyladenines: structure-activity relationships of potent A1 selective adenosine receptor antagonists.
J Med Chem. 1990 Oct;33(10):2822-8. doi: 10.1021/jm00172a023.
5
N6-phenyladenosines: pronounced effect of phenyl substituents on affinity for A2 adenosine receptors.N6-苯基腺苷：苯基取代基对A2腺苷受体亲和力有显著影响。
J Med Chem. 1987 May;30(5):954-6. doi: 10.1021/jm00388a039.
6
N6-substituted N-alkyladenosine-5'-uronamides: bifunctional ligands having recognition groups for A1 and A2 adenosine receptors.N6-取代的N-烷基腺苷-5'-脲酰胺：对A1和A2腺苷受体具有识别基团的双功能配体。
J Med Chem. 1986 Sep;29(9):1683-9. doi: 10.1021/jm00159a020.
7
Structure-activity relationships of N6-benzyladenosine-5'-uronamides as A3-selective adenosine agonists.N6-苄基腺苷-5'-脲酰胺作为A3选择性腺苷激动剂的构效关系
J Med Chem. 1994 Mar 4;37(5):636-46. doi: 10.1021/jm00031a014.
8
1H-imidazo[4,5-c]quinolin-4-amines: novel non-xanthine adenosine antagonists.
J Med Chem. 1991 Mar;34(3):1202-6. doi: 10.1021/jm00107a046.
9
Characterization of the A2 adenosine receptor labeled by [3H]NECA in rat striatal membranes.用[3H]NECA标记的大鼠纹状体膜中A2腺苷受体的特性研究。
Mol Pharmacol. 1986 Apr;29(4):331-46.
10
2-Alkynyl derivatives of adenosine-5'-N-ethyluronamide: selective A2 adenosine receptor agonists with potent inhibitory activity on platelet aggregation.腺苷-5'-N-乙基脲酰胺的2-炔基衍生物：对血小板聚集具有强效抑制活性的选择性A2腺苷受体激动剂。
J Med Chem. 1994 May 27;37(11):1720-6. doi: 10.1021/jm00037a024.

引用本文的文献

1
Recent Developments in Selective Agonists and Antagonists Acting at Purine and Pyrimidine Receptors.作用于嘌呤和嘧啶受体的选择性激动剂和拮抗剂的最新进展。
Drug Dev Res. 1996 Nov-Dec;39(3-4):289-300. doi: 10.1002/(sici)1098-2299(199611/12)39:3/4<289::aid-ddr8>3.0.co;2-n.
2
A adenosine receptor agonists, antagonists, inverse agonists and partial agonists.腺嘌呤核苷受体激动剂、拮抗剂、反向激动剂和部分激动剂。
Int Rev Neurobiol. 2023;170:1-27. doi: 10.1016/bs.irn.2023.08.001. Epub 2023 Aug 25.
3
The role of peripheral adenosine receptors in glutamate-induced pain nociceptive behavior.
外周腺苷受体在谷氨酸诱导的疼痛伤害性行为中的作用。
Purinergic Signal. 2021 Jun;17(2):303-312. doi: 10.1007/s11302-021-09781-y. Epub 2021 Apr 16.
4
Semisynthesis, Characterization and Evaluation of New Adenosine Derivatives as Antiproliferative Agents.新型腺嘌呤衍生物的半合成、表征及作为抗增殖剂的评价。
Molecules. 2018 May 8;23(5):1111. doi: 10.3390/molecules23051111.
5
Docking studies of agonists and antagonists suggest an activation pathway of the A3 adenosine receptor.激动剂和拮抗剂的对接研究表明了A3腺苷受体的激活途径。
J Mol Graph Model. 2006 Dec;25(4):562-77. doi: 10.1016/j.jmgm.2006.05.004. Epub 2006 May 9.
6
Adenosine receptors as therapeutic targets.腺苷受体作为治疗靶点。
Nat Rev Drug Discov. 2006 Mar;5(3):247-64. doi: 10.1038/nrd1983.
7
Structural determinants of efficacy at A3 adenosine receptors: modification of the ribose moiety.A3 腺苷受体效能的结构决定因素：核糖部分的修饰
Biochem Pharmacol. 2004 Mar 1;67(5):893-901. doi: 10.1016/j.bcp.2003.10.006.
8
International Union of Pharmacology. XXV. Nomenclature and classification of adenosine receptors.国际药理学联合会。二十五。腺苷受体的命名和分类。
Pharmacol Rev. 2001 Dec;53(4):527-52.
9
Adenosine-mediated presynaptic modulation of glutamatergic transmission in the laterodorsal tegmentum.腺苷介导的外侧背盖区谷氨酸能传递的突触前调制
J Neurosci. 2001 Feb 1;21(3):1076-85. doi: 10.1523/JNEUROSCI.21-03-01076.2001.
10
ATP and glutamate are released from separate neurones in the rat medial habenula nucleus: frequency dependence and adenosine-mediated inhibition of release.三磷酸腺苷（ATP）和谷氨酸从大鼠内侧缰核中的不同神经元释放：频率依赖性以及腺苷介导的释放抑制。
J Physiol. 1998 May 1;508 ( Pt 3)(Pt 3):691-701. doi: 10.1111/j.1469-7793.1998.691bp.x.