Brooklyn College Cancer Center BCCC-CURE, Brooklyn College, The City University of New York, 2900 Bedford Avenue, Brooklyn, New York, 11210, USA.
Department of Chemistry, Brooklyn College, The City University of New York, 2900 Bedford Avenue, Brooklyn, New York, 11210, USA.
Chemistry. 2021 Jun 21;27(35):8891-8917. doi: 10.1002/chem.202100438. Epub 2021 May 5.
This review focuses on studies of coordination and organometallic compounds as potential chemotherapeutics against triple negative breast cancer (TNBC) which has one of the poorest prognoses and worst survival rates from all breast cancer types. At present, chemotherapy is still the standard of care for TNBC since only one type of targeted therapy has been recently developed. References for metal-based compounds studied in TNBC cell lines will be listed, and those of metal-specific reviews, but a detailed overview will also be provided on compounds studied in vivo (mostly in mice models) and those compounds for which some preliminary mechanistic data was obtained (in TNBC cell lines and tumors) and/or for which bioactive ligands have been used. The main goal of this review is to highlight the most promising metal-based compounds with potential as chemotherapeutic agents in TNBC.
这篇综述主要关注作为治疗三阴性乳腺癌（TNBC）的潜在化疗药物的配合物和金属有机化合物的研究。三阴性乳腺癌是所有乳腺癌中预后最差、生存率最低的一种。目前，由于最近仅开发出一种靶向治疗药物，化疗仍然是 TNBC 的标准治疗方法。本文将列出在 TNBC 细胞系中研究的基于金属的化合物的参考文献，以及金属特异性综述的参考文献，但也将提供在体内（主要在小鼠模型中）研究的化合物以及获得一些初步机制数据的化合物（在 TNBC 细胞系和肿瘤中）和/或已用于生物活性配体的化合物的详细概述。本篇综述的主要目的是强调最有前途的基于金属的化合物，它们具有作为 TNBC 化疗药物的潜力。
