Mackenzie Evangelical School of Medicine Paraná, Curitiba, Brazil.
Lupus. 2021 Jun;30(7):1197-1202. doi: 10.1177/09612033211010330. Epub 2021 Apr 15.
Systemic lupus erythematosus (SLE) may have a different serological and clinical profile according to age of disease onset.
To compare clinical presentation and serological data from patients with SLE onset in childhood (cSLE) with disease onset in adulthood (aSLE) in a sample of Brazilian patients.
Retrospective study of 614 SLE patients from a single Rheumatology Unit from Brazil: 77 (12.5%) cSLE and 537 (87.4%) aSLE. Clinical and serological data were obtained from the charts. Comparisons of cSLE with aSLE in general and according to patient's gender were made.
The comparison of whole sample showed that children had more malar rash (p = 0.04), seizures (p < 0.0001), psychosis (p = 0.02), glomerulonephritis (p = 0.001), anti-dsDNA (p = 0.008), anticardiolipin IgM (p = 0.04) but less discoid lesions (p = 0.01), anti-Ro (p < 0.0001) and anti-La antibodies (p = 0.007). When only the male sample was compared, no differences in glomerulonephritis and anti-dsDNA frequencies were found.
Children had a higher frequency of severe manifestations (glomerulonephritis and central nervous system) than adults. The difference in glomerulonephritis occurrence disappeared when only males were compared.
系统性红斑狼疮（SLE）的发病年龄不同，其血清学和临床表现可能也有所不同。
比较巴西患者样本中儿童起病（cSLE）和成人起病（aSLE）的SLE 患者的临床表现和血清学数据。
回顾性分析来自巴西单一风湿病单位的 614 例 SLE 患者：77 例（12.5%）为 cSLE，537 例（87.4%）为 aSLE。从病历中获取临床和血清学数据。比较 cSLE 和 aSLE 患者的总体情况，并根据患者性别进行比较。
全样本比较显示，儿童有更多的蝶形红斑（p=0.04）、癫痫发作（p<0.0001）、精神病（p=0.02）、肾小球肾炎（p=0.001）、抗双链 DNA（p=0.008）、抗心磷脂 IgM（p=0.04），但盘状皮损（p=0.01）、抗 Ro（p<0.0001）和抗 La 抗体（p=0.007）较少。仅比较男性样本时，肾小球肾炎和抗 dsDNA 频率无差异。
儿童的严重表现（肾小球肾炎和中枢神经系统）发生率高于成人。仅比较男性时，肾小球肾炎的发生率差异消失。
