Department of Neurology, Children's National Hospital, 111 Michigan Ave NW, Washington, DC 20010, United States.
Department of Neurology, Georgetown University Medical Center, 37th and O Street, N.W., Washington, DC 20057, United States.
Neuroimage Clin. 2021;30:102598. doi: 10.1016/j.nicl.2021.102598. Epub 2021 Mar 1.
Development of a task-free method for presurgical mapping of language function is important for use in young or cognitively impaired patients. Resting state connectivity fMRI (RS-fMRI) is a task-free method that may be used to identify cognitive networks. We developed a voxelwise RS-fMRI metric, Functional Connectivity Hemispheric Contrast (FC-HC), to map the language network and determine language laterality through comparison of within-hemispheric language network connections (Integration) to cross-hemispheric connections (Segregation). For the first time, we demonstrated robustness and efficacy of a RS-fMRI metric to map language networks across five groups (total N = 243) that differed in MRI scanning parameters, fMRI scanning protocols, age, and development (typical vs pediatric epilepsy). The resting state FC-HC maps for the healthy pediatric and adult groups showed higher values in the left hemisphere, and had high agreement with standard task language fMRI; in contrast, the epilepsy patient group map was bilateral. FC-HC has strong but not perfect agreement with task fMRI and thus, may reflect related and complementary information about language plasticity and compensation.
开发一种无任务的方法来进行术前语言功能定位对于在年轻或认知受损的患者中使用非常重要。静息状态功能磁共振连接成像（RS-fMRI）是一种无任务的方法，可用于识别认知网络。我们开发了一种基于体素的 RS-fMRI 指标，功能连接半球对比（FC-HC），通过比较半球内语言网络连接（整合）与跨半球连接（分离）来绘制语言网络并确定语言侧化。我们首次证明了 RS-fMRI 指标在五个不同的群体（总共 243 人）中绘制语言网络的稳健性和有效性，这些群体在 MRI 扫描参数、fMRI 扫描方案、年龄和发育（典型与儿科癫痫）方面存在差异。健康儿科和成人组的静息状态 FC-HC 图显示左半球的数值较高，与标准任务 fMRI 高度一致；相比之下，癫痫患者组的图则是双侧的。FC-HC 与任务 fMRI 具有较强但非完美的一致性，因此可能反映了与语言可塑性和补偿相关且互补的信息。
