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N Engl J Med. 2017 Jan 12;376(2):125-135. doi: 10.1056/NEJMoa1607427.
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Parathyroid hormone-related peptide (PTHrP) secretion by gastroenteropancreatic neuroendocrine tumors (GEP-NETs): clinical features, diagnosis, management, and follow-up.胃肠胰神经内分泌肿瘤（GEP-NETs）分泌甲状旁腺激素相关肽（PTHrP）：临床特征、诊断、管理及随访
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Humoral hypercalcemia of malignancy caused by parathyroid hormone-related peptide-secreting neuroendocrine tumors. Report of six cases.由甲状旁腺激素相关肽分泌的神经内分泌肿瘤引起的恶性肿瘤所致体液性高钙血症。六例报告。
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罕见的胰腺神经内分泌肿瘤表现为副肿瘤性高钙血症。

Rare case of pancreatic neuroendocrine tumour presenting as paraneoplastic hypercalcaemia.

机构信息

Department of Surgical Oncology, MercyOne Medical Center, Des Moines, Iowa, USA.

Department of Surgical Oncology, MercyOne Medical Center, Des Moines, Iowa, USA

出版信息

BMJ Case Rep. 2021 Apr 15;14(4):e240786. doi: 10.1136/bcr-2020-240786.

DOI:10.1136/bcr-2020-240786
PMID:33858893
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8054046/
Abstract

An asymptomatic 68-year-old woman who presented with an isolated hypercalcaemia was diagnosed with a rare, previously unsuspected parathyroid hormone-related peptide (PTHrP)-producing pancreatic neuroendocrine tumour. She underwent an extensive operation including vascular resection and reconstruction, resulting in successful removal of the tumour with negative margins. Medical and surgical management of pancreatic neuroendocrine tumours and PTHrP-mediated paraneoplastic hypercalcaemia is discussed.

摘要

一位 68 岁无症状女性因孤立性高钙血症就诊，被诊断为一种罕见的、以前未被怀疑的甲状旁腺激素相关肽（PTHrP）产生的胰腺神经内分泌肿瘤。她接受了广泛的手术，包括血管切除和重建，成功地切除了肿瘤，切缘阴性。讨论了胰腺神经内分泌肿瘤和 PTHrP 介导的副肿瘤性高钙血症的药物和手术治疗。