College of Animal Science and National Engineering Research Center for Breeding Swine Industry, South China Agricultural University, Guangzhou, Guangdong 510642, China.
Mediators Inflamm. 2021 Mar 29;2021:5577577. doi: 10.1155/2021/5577577. eCollection 2021.
Macrophages are multifunctional immune cells whose functions depend on polarizable phenotypes and the microenvironment. Macrophages have two phenotypes, including the M1 proinflammatory phenotype and the M2 anti-inflammatory phenotype, which play important roles in many inflammatory responses and diseases. -Ketoglutarate is a key metabolite of the TCA cycle and can regulate the phenotype of macrophage polarization to exert anti-inflammatory effects in many inflammation-related diseases. In this review, we primarily elucidate the metabolism, regulatory mechanism, and perspectives of -ketoglutarate on macrophages. The regulation of macrophage polarization by -ketoglutarate may provide a promising target for the prevention and therapy of inflammatory diseases and is beneficial to animal health.
巨噬细胞是多功能免疫细胞，其功能取决于可极化的表型和微环境。巨噬细胞有两种表型，包括 M1 促炎表型和 M2 抗炎表型，它们在许多炎症反应和疾病中发挥重要作用。α-酮戊二酸是 TCA 循环的关键代谢物，可调节巨噬细胞极化的表型，在许多与炎症相关的疾病中发挥抗炎作用。在这篇综述中，我们主要阐明了 α-酮戊二酸的代谢、调节机制以及对巨噬细胞的影响。α-酮戊二酸对巨噬细胞极化的调节可能为炎症性疾病的预防和治疗提供有希望的靶点，有利于动物健康。
