Pei Minghang, Liu Xinshu, Yang Peizeng, Zhao Chan, Gao Fei, Qu Yi, Liang Anyi, Xiao Junyan, Zhang Meifen
Department of Ophthalmology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Department of Ophthalmology, The Fourth People's Hospital of Shenyang, Shenyang, China.
Front Immunol. 2021 Mar 25;12:589639. doi: 10.3389/fimmu.2021.589639. eCollection 2021.
Interleukin (IL)33, a member of the IL1 superfamily, functions as a nuclear factor and mediates biological effects by interacting with the ST2 receptor. Recent studies have described IL33 as an emerging pro-inflammatory cytokine in the immune system, and / gene polymorphisms have been implicated in the pathogenesis of various immune diseases. However, the underlying mechanisms of in Behcet's disease (BD) remain to be defined. Here, we investigated the association between gene polymorphisms and BD in 585 BD uveitis (BDU) patients and 834 healthy controls using Agena MassARRAY iPLEX platform. We found that rs3821204 was associated with the development of BDU. Moreover, the frequency of rs2210463 G allele was lower in patients with genital involvement. Association analysis revealed a much greater genetic difference between complete-type and incomplete-type BD groups, including three SNPs (rs7044343, rs1048274, and rs2210463). Our findings suggest that gene polymorphisms are involved in the pathogenesis of BDU. Different genetic backgrounds may exist in complete-type and incomplete-type BD patients.
白细胞介素（IL）-33是IL-1超家族的成员，作为一种核因子，通过与ST2受体相互作用介导生物学效应。最近的研究将IL-33描述为免疫系统中一种新出现的促炎细胞因子，并且其基因多态性与多种免疫疾病的发病机制有关。然而，其在白塞病（BD）中的潜在机制仍有待明确。在此，我们使用Agena MassARRAY iPLEX平台，对585例白塞病葡萄膜炎（BDU）患者和834例健康对照者进行研究，以探讨IL-33基因多态性与BD的关联。我们发现rs3821204与BDU的发生有关。此外，生殖器受累患者中rs2210463 G等位基因的频率较低。关联分析显示，完全型和不完全型BD组之间存在更大的遗传差异，包括三个单核苷酸多态性（SNP，rs7044343、rs1048274和rs2210463）。我们的研究结果表明，IL-33基因多态性参与了BDU的发病机制。完全型和不完全型BD患者可能存在不同的遗传背景。
