Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, No. 119 South Fourth Ring Rd West, Fengtai District, Beijing 100070, China.
China National Clinical Research Center for Neurological Diseases, Beijing 100070, China.
Dis Markers. 2021 Mar 30;2021:8862299. doi: 10.1155/2021/8862299. eCollection 2021.
We aimed to investigate the risk factors associated with hemorrhage and clarify the relation of homocysteine (Hcy) with brain arteriovenous malformations (bAVMs).
We retrospectively reviewed bAVM patients from Beijing Tiantan Hospital between January 2019 and December 2019. Clinical and laboratory variables were analyzed in enrolled patients with bAVMs. Potential predictors associated with hemorrhage were evaluated by logistic regression analysis.
A total of 143 bAVM patients were identified in the study, including 69 unruptured and 74 ruptured cases. Patients with hemorrhage were less likely to have hyperhomocysteinemia ( = 0.023). Logistic regression analysis showed that increased maximum diameter of bAVM lesions (odds ratio (OR) 0.634, 95% confidence intervals (CI) 0.479-0.839; = 0.001) and serum Hcy level (OR 0.956, 95% CI 0.920-0.993; = 0.021) were associated with lower risk of hemorrhage in bAVMs.
The present study provided evidence regarding the association between serum Hcy and hemorrhage in patients with bAVMs. Higher Hcy level was correlated with a lower risk of rupture. Detection of factors for subsequent hemorrhage is necessary to develop therapeutic strategies for bAVMs preferably.
本研究旨在探讨与出血相关的危险因素，并阐明同型半胱氨酸（Hcy）与脑动静脉畸形（bAVM）之间的关系。
我们回顾性分析了 2019 年 1 月至 2019 年 12 月期间在北京天坛医院就诊的 bAVM 患者。对入组的 bAVM 患者进行临床和实验室变量分析。采用 logistic 回归分析评估与出血相关的潜在预测因素。
本研究共纳入 143 例 bAVM 患者，其中 69 例为未破裂型，74 例为破裂型。出血患者发生高同型半胱氨酸血症的可能性较低（ = 0.023）。logistic 回归分析显示，bAVM 病变最大直径增加（比值比（OR）0.634，95%置信区间（CI）0.479-0.839； = 0.001）和血清 Hcy 水平降低（OR 0.956，95% CI 0.920-0.993； = 0.021）与 bAVM 出血风险降低相关。
本研究提供了有关 bAVM 患者血清 Hcy 与出血之间关系的证据。较高的 Hcy 水平与较低的破裂风险相关。检测与随后出血相关的因素对于制定 bAVM 的治疗策略是必要的。
