Association of neurogranin gene expression with Alzheimer's disease pathology in the perirhinal cortex.

INTRODUCTION

Synaptic damage is a key pathology of Alzheimer's disease (AD). The mechanism underlying synaptic vulnerability in AD remains elusive.

METHODS

Using a large-scale transcriptomic dataset, we analyzed the neurogranin-centered integrative gene network and assessed the correlation of neurogranin () gene expression with AD pathology in brains. We studied the association of expression with Clinical Dementia Rating (CDR) and neuropathological diagnosis of AD.

RESULTS

We find that the genes positively correlated with expression in AD are involved in synaptic transmission and cation channel pathways. expression is correlated with amyloid and tau pathology in the perirhinal cortex of brains. expression is associated with the diagnosis of AD and correlated with CDR.

DISCUSSION

Transcriptional regulation of the gene encoding for synaptic protein is involved in selective synaptic damage in AD. Identifying the genes associated with synaptic damage pathways in AD may provide targets for intervention.