Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
Medicinal Plants Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
J Pept Sci. 2021 Jul;27(7):e3329. doi: 10.1002/psc.3329. Epub 2021 Apr 15.
Tyrosinase is a copper-containing enzyme involved in the biosynthesis of melanin pigment, which is the most important photo protective agent against skin photo carcinogenesis. Excess production of melanin causes hyperpigmentation leading to undesired browning in human skin, fruits, and vegetable as well as plant-derived foods. Moreover, the role of tyrosinase in the onset and progression of various diseases such as cancers, Alzheimer's, and Parkinson diseases has been well documented in the literature. In this respect, tyrosinase inhibitors have been in the center of attention particularly as the efficient skin whitening agents. Among a wide range of compounds possessing anti-tyrosinase activity, peptides both natural and synthetic derivatives have attracted attention due to high potency and safety.
酪氨酸酶是一种含铜酶，参与黑色素的生物合成，黑色素是皮肤光致癌作用最重要的光保护剂。过量的黑色素会导致色素沉着，导致人体皮肤、水果和蔬菜以及植物性食品出现不需要的褐色化。此外，文献中已有大量记载表明，酪氨酸酶在各种疾病（如癌症、阿尔茨海默病和帕金森病）的发生和发展中起作用。在这方面，酪氨酸酶抑制剂一直是人们关注的焦点，特别是作为有效的皮肤美白剂。在具有抗酪氨酸酶活性的广泛化合物中，由于效力高、安全性好，天然和合成衍生肽引起了人们的关注。
