Department of Otolaryngology-Head and Neck Surgery, The University of Texas Southwestern Medical Center, Dallas, Texas, U.S.A.
Division of Pediatric Otolaryngology, Children's Health, Children's Medical Center Dallas, Dallas, Texas, U.S.A.
Laryngoscope. 2021 Nov;131(11):2598-2602. doi: 10.1002/lary.29575. Epub 2021 Apr 16.
OBJECTIVES/HYPOTHESIS: To determine whether the severity of obstructive sleep apnea (OSA) is affected by weight gain velocity (WGV) in adolescents with Down syndrome.
Retrospective case series.
We performed a retrospective case series of children with Down syndrome, aged 9-19, referred for polysomnography (PSG) due to suspected OSA at an academic children's hospital. We determined the velocity (slope of change) of yearly weight gain using a mixed effect linear regression model. Subsequently, we determined if velocity of yearly weight gain was greater in adolescents with severe OSA (apnea-hypopnea index > 10). Significance was set at P < .05.
A total of 77 adolescents with Down syndrome were identified. The average age was 12.5 years (standard deviation = 3.1); 44 (57%) were male and 46 (60%) were Hispanic. The majority, 51 (66%) had severe OSA. The velocity of yearly weight gain prior to PSG in Down syndrome adolescents was similar regardless of OSA severity (mean diff in weight gain at PSG between severe and nonsevere OSA = -1.42, 95% confidence interval = -5.8 to 2.9, P = .52). Down syndrome adolescents with severe OSA weighed more at PSG (58.4 kg vs. 40.9 kg, P < .001) and all years prior to PSG. These findings remained even when controlling for age at PSG.
Severe OSA in adolescents with Down syndrome is associated with weight. There was no significant difference in WGV in children with Down syndrome with or without severe OSA.
3 Laryngoscope, 131:2598-2602, 2021.
目的/假设：确定唐氏综合征青少年阻塞性睡眠呼吸暂停（OSA）的严重程度是否受体重增长速度（WGV）的影响。
回顾性病例系列研究。
我们对一家学术儿童医院因疑似 OSA 而接受多导睡眠图（PSG）检查的唐氏综合征儿童进行了回顾性病例系列研究。我们使用混合效应线性回归模型确定每年体重增加的速度（变化的斜率）。随后，我们确定重度 OSA （呼吸暂停-低通气指数> 10）青少年的体重增长速度是否更快。设 P <.05 为有统计学意义。
共纳入 77 例唐氏综合征青少年。平均年龄为 12.5 岁（标准差=3.1）；44 例（57%）为男性，46 例（60%）为西班牙裔。大多数（51 例，66%）患有重度 OSA。唐氏综合征青少年在 PSG 前的体重增长速度与 OSA 严重程度无关（PSG 时重度和非重度 OSA 之间体重增加的差异均值为-1.42，95%置信区间为-5.8 至 2.9，P=0.52）。患有重度 OSA 的唐氏综合征青少年在 PSG 时体重更重（58.4kg 比 40.9kg，P <.001），并且在 PSG 之前的所有年份体重都更重。即使在控制 PSG 时的年龄后，这些发现仍然存在。
唐氏综合征青少年重度 OSA 与体重有关。患有或不患有重度 OSA 的唐氏综合征儿童的 WGV 无显著差异。
3 级喉镜，131:2598-2602，2021 年。
