Wang Dan, Zhao Rong, Duan Hu-Xinyue, Zhang Meng-Meng, He Lin, Ye Xun, Wei Da-Neng, Wu Chun-Jie
School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
J Pharm Pharmacol. 2021 Jul 7;73(8):1007-1022. doi: 10.1093/jpp/rgaa054.
Postoperative intestinal obstruction is a common postoperative complication with typical symptoms of abdominal pain, vomiting, abdominal distension and constipation. The principal aim of this paper is to provide a full-scale review on the categories and characteristics of postoperative intestinal obstruction, pathophysiology, effects and detailed mechanisms of compounds and monomers from traditional Chinese medicine for treating postoperative intestinal obstruction. Moreover, the possible development and perspectives for future research are also analyzed.
Literature regarding postoperative intestinal obstruction as well as the anti-pio effect of aqueous extracts and monomers from traditional Chinese medicine in the last 20 years was summarized.
To date, approximately 30 compounds and 25 monomers isolated from traditional Chinese medicine including terpenes, alkaloids, polysaccharides, flavonoids, phenylpropanoids and quinones, have exerted significant antipio effect. This paper reviews the effective doses, models, detailed mechanisms, and composition of these traditional Chinese medicine compounds, as well as the structure of these monomers. Moreover, challenges existed in the current investigation and further perspectives were discussed as well, hoping to provide a reference for future clinical treatment of postoperative intestinal obstruction and the development of new drugs.
Above all, the convincing evidence from modern pharmacology studies powerfully supported the great potential of traditional Chinese medicine in the management of postoperative intestinal obstruction. Regrettably, less attention was currently paid on the mechanisms of traditional Chinese medicine compounds and monomers with antipio effect. Consequently, future study should focus on monomer-mechanism and structure-function relationship.
术后肠梗阻是一种常见的术后并发症，具有腹痛、呕吐、腹胀和便秘等典型症状。本文的主要目的是全面综述术后肠梗阻的类别和特点、病理生理学、中药复方及单体治疗术后肠梗阻的作用、详细机制。此外，还分析了未来研究可能的发展方向和前景。
总结了过去20年中关于术后肠梗阻以及中药水提取物和单体抗术后肠梗阻作用的文献。
迄今为止，从中药中分离出的约30种化合物和25种单体，包括萜类、生物碱、多糖、黄酮类、苯丙素类和醌类，已发挥出显著的抗术后肠梗阻作用。本文综述了这些中药化合物的有效剂量、模型、详细机制和组成，以及这些单体的结构。此外，还讨论了当前研究中存在的挑战和进一步的前景，希望为术后肠梗阻的未来临床治疗和新药开发提供参考。
最重要的是，现代药理学研究的有力证据有力地支持了中药在治疗术后肠梗阻方面的巨大潜力。遗憾的是，目前对具有抗术后肠梗阻作用的中药化合物和单体的作用机制关注较少。因此，未来的研究应集中在单体-机制和结构-功能关系上。
