Zhou Pengfei, Yang Huiju, Wang Jiawen, Sun Mingming, Yan Shuai
Department of Anorectal Surgery, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Department of Aolorectal Surgery, The Third Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou, China.
Front Med (Lausanne). 2025 May 2;12:1573655. doi: 10.3389/fmed.2025.1573655. eCollection 2025.
Adhesive intestinal obstruction (AIO) represents a common postoperative complication, particularly following abdominal surgery, with reported incidence rates varying between 50 and 80%. Traditional Chinese Medicine (TCM) has proven clinically effective in managing AIO, offering diverse therapeutic approaches that facilitate multi-pathway and multi-target treatment. Clinical evidence consistently supports the favorable safety profile of Traditional Chinese Medicine (TCM). Nevertheless, several critical challenges remain to be addressed, including its complex multi-component nature, insufficiently elucidated mechanisms of action, lack of precise dosage standards, inconsistencies in decoction preparation methods, inconvenient administration procedures, and a paucity of large-scale, multicenter clinical trials with robust evidence. These barriers hinder the widespread adoption and clinical integration of TCM. Moving forward, large-scale, multicenter studies are essential to further investigate the safety and efficacy of TCM. Moreover, reforms in its administration methods and deeper exploration of its mechanisms in AIO treatment are crucial.
粘连性肠梗阻（AIO）是一种常见的术后并发症，尤其是在腹部手术后，据报道其发病率在50%至80%之间。中医在治疗AIO方面已被证明具有临床疗效，提供了多种治疗方法，有助于多途径、多靶点治疗。临床证据一直支持中医良好的安全性。然而，仍有几个关键挑战有待解决，包括其成分复杂、作用机制尚未充分阐明、缺乏精确的剂量标准、汤剂制备方法不一致、给药程序不便以及缺乏具有有力证据的大规模、多中心临床试验。这些障碍阻碍了中医的广泛应用和临床整合。展望未来，大规模、多中心研究对于进一步研究中医的安全性和有效性至关重要。此外，改革其给药方法并深入探索其在AIO治疗中的机制至关重要。
