见树又见林——单细胞图谱将 CD8 T 细胞和巨噬细胞与肾癌的疾病进展和治疗反应联系起来。

Seeing the forest for the trees-single-cell atlases link CD8 T cells and macrophages to disease progression and treatment response in kidney cancer.

机构信息

Huntsman Cancer Institute, University of Utah, 2000 Circle of Hope Drive, Salt Lake City, UT 84112; Department of Pharmacology and Toxicology, University of Utah, 30S 2000E, Salt Lake City, UT 84112.

Huntsman Cancer Institute, University of Utah, 2000 Circle of Hope Drive, Salt Lake City, UT 84112.

出版信息

Cancer Cell. 2021 May 10;39(5):594-596. doi: 10.1016/j.ccell.2021.03.008. Epub 2021 Apr 15.

DOI:10.1016/j.ccell.2021.03.008

PMID:33861995

Abstract

Intra- and interpatient heterogeneity of clear cell renal cell carcinoma (ccRCC) confounds the search for therapies associated with durable tumor responses and predictive biomarkers. Here, Braun et. al., Krishna et.al, and Bi et.al. use single-cell mRNA sequencing to characterize progressive immune dysfunction associated with ccRCC progression and resistance to immunotherapies.

摘要

透明细胞肾细胞癌 (ccRCC) 的肿瘤内和肿瘤间异质性使得与持久肿瘤反应和预测性生物标志物相关的治疗方法的研究变得复杂。在这里，Braun 等人、Krishna 等人和 Bi 等人使用单细胞 mRNA 测序来描述与 ccRCC 进展和免疫治疗耐药相关的进行性免疫功能障碍。