Department of Discovery Medicine, Pathology Division, Graduate School of Medicine, Kyoto University, Yoshida-Konoe-cho, Sakyo-ku, Kyoto 606-8315, Japan; Tazukofukai Medical Institute Kitano Hospital, Ogimachi, 2-4-20, Osaka 530-8480, Osaka, Japan.
J Theor Biol. 2021 Aug 21;523:110716. doi: 10.1016/j.jtbi.2021.110716. Epub 2021 Apr 14.
Cell signal transduction is an example of a nonequilibrium phenomenon. In this study, a nonequilibrium nonlinear thermodynamic model was formulated. First, we obtained a condition in which the Onsager's reciprocity theorem holds in the signal transduction. Second, it was found that the entropy production rate per signal molecule is conserved through signal transduction. Finally, it was determined that when Onsager's reciprocity theorem does not hold, fluctuation circulation is given by the phosphorylation rate of signal molecules. The simple relation implies that the fluctuation circulation can be an essential quantity of the signal transduction amount. These results expand the limit of nonequilibrium thermodynamics and can be used to provide ideas for signal transduction quantification.
细胞信号转导是一种非平衡现象的例子。在这项研究中，我们建立了一个非平衡非线性热力学模型。首先，我们得到了信号转导中满足昂萨格倒易关系的条件。其次，我们发现信号分子的熵产生速率在信号转导过程中是守恒的。最后，我们确定了当昂萨格倒易关系不成立时，波动循环由信号分子的磷酸化速率给出。这种简单的关系意味着波动循环可以成为信号转导量的一个基本数量。这些结果扩展了非平衡热力学的范围，可以用来为信号转导的量化提供思路。
