Huang Bing, Yao Ming, Chen QiLiang, Lin Huidan, Du Xindan, Huang Hao, Zhao Xian, Do Huy, Qian Xiang
1Department of Pain Medicine, The Affiliated Hospital of Jiaxing University, Jiaxing City, Zhejiang, People's Republic of China.
2Department of Anesthesiology, Perioperative and Pain Medicine, Stanford University, Palo Alto, California.
J Neurosurg. 2021 Apr 16;135(5):1459-1465. doi: 10.3171/2020.10.JNS203209. Print 2021 Nov 1.
Hemifacial spasm (HFS) is a debilitating neuromuscular disorder with limited treatment options. The current study describes a novel minimally invasive procedure that provided effective and sustained relief for patients with HFS. The authors provide a detailed description of the awake CT-guided percutaneous radiofrequency ablation (RFA) of the facial nerve for treatment of HFS, and they examine its clinical efficacy. This is the first time in the literature that this procedure has been applied and systematically analyzed for HFS.
Patients with a history of HFS were recruited between August 2018 and April 2020. Those with a history of cerebellopontine lesions, coagulopathy, ongoing pregnancy, cardiac pacemaker or defibrillator implants, or who declined the procedure were excluded from the study. Fifty-three patients who met the study criteria were included and underwent awake CT-guided RFA. Under minimal sedation, a radiofrequency (RF) needle was used to reach the stylomastoid foramen on the affected side under CT guidance, and the facial nerve was localized using a low-frequency stimulation current. Patients were instructed to engage facial muscles as a proxy for motor monitoring during RFA. Ablation stopped when the patients' hemifacial contracture resolved. Patients were kept for inpatient monitoring for 24 hours postoperatively and were followed up monthly to monitor resolution of HFS and complications for up to 19 months.
The average duration of the procedure was 32-34 minutes. Postoperatively, 91% of the patients (48/53) had complete resolution of HFS, whereas the remaining individuals had partial resolution. A total of 48 patients reported mild to moderate facial paralysis immediately post-RFA, but most resolved within 1 month. No other significant complication was observed during the study period. By the end of the study period, 5 patients had recurrence of mild HFS symptoms, whereas only 2 patients reported dissatisfaction with the treatment results.
The authors report for the first time that awake CT-guided RFA of the facial nerve at the stylomastoid foramen is a minimally invasive procedure and can be an effective treatment option for HFS.
半面痉挛(HFS)是一种使人衰弱的神经肌肉疾病,治疗选择有限。本研究描述了一种新型微创手术,可为HFS患者提供有效且持久的缓解。作者详细描述了清醒状态下CT引导的面神经经皮射频消融术(RFA)治疗HFS,并检验其临床疗效。这是该手术首次在文献中应用于HFS并进行系统分析。
2018年8月至2020年4月招募有HFS病史的患者。有桥小脑病变史、凝血功能障碍、正在妊娠、植入心脏起搏器或除颤器者,或拒绝该手术者被排除在研究之外。纳入53例符合研究标准的患者并接受清醒状态下CT引导的RFA。在最小镇静状态下,使用射频(RF)针在CT引导下到达患侧茎乳孔,并使用低频刺激电流定位面神经。在RFA期间,指导患者收缩面部肌肉作为运动监测的替代方法。当患者的半面挛缩消失时停止消融。术后患者住院监测24小时,并每月随访以监测HFS的缓解情况和并发症,最长随访19个月。
手术平均时长为32 - 34分钟。术后,91%的患者(48/53)HFS完全缓解,其余患者部分缓解。共有48例患者在RFA后立即报告有轻度至中度面瘫,但大多数在1个月内恢复。研究期间未观察到其他严重并发症。到研究结束时,5例患者出现轻度HFS症状复发,而只有2例患者对治疗结果表示不满意。
作者首次报告,清醒状态下CT引导的茎乳孔面神经RFA是一种微创手术,可为HFS提供有效的治疗选择。