Allen B D, Sutanto W, Jones M T
Human Physiology Department, Royal Holloway and Bedford New College (University of London), Egham, Surrey, England.
J Steroid Biochem. 1988;30(1-6):411-5. doi: 10.1016/0022-4731(88)90133-1.
Dexamethasone inhibitory action on the release of adrenocorticotrophin has been studied using in vitro anterior pituitary preparations. This inhibition is reversed when the animal is given the antiglucocorticoid compound RU38486 simultaneously with dexamethasone. RU38486 acts at the receptor level and in the cytosolic binding study, it competes with [3H]dexamethasone for the binding sites in pituitary. Such competition is even more pronounced in hypothalamus and hippocampus, indicating that RU38486 also exert its antagonistic action at these sites.
已使用体外垂体前叶制剂研究了地塞米松对促肾上腺皮质激素释放的抑制作用。当给动物同时给予抗糖皮质激素化合物RU38486和地塞米松时，这种抑制作用会被逆转。RU38486在受体水平起作用，在细胞溶质结合研究中，它与[3H]地塞米松竞争垂体中的结合位点。这种竞争在丘脑下部和海马体中更为明显，表明RU38486在这些部位也发挥其拮抗作用。
