Radomirov R, Venkova K, Ilieva E
Institute of Physiology, Bulgarian Academy of Sciences, Sofia.
Methods Find Exp Clin Pharmacol. 1988 Apr;10(4):227-9.
Contractile responses of the longitudinal muscle layer of guinea pig ileum to 40-sec electrical field stimulation (0.8 msec, 20 V) applied at frequencies of 5 Hz or 30 Hz consisted in a fast phasic contraction followed by a low-amplitude tonic component. Atropin (3 microM) and prazosine (1 microM) decreased significantly the amplitude of the phasic contraction and had less influence on the tonic component. SC 19220 (50 microM) additionally lowered both the fast and the tonic contractions, the inhibitory effect being more pronounced on the tonic component. It is suggested that prostaglandins released during electrical stimulation could be involved in the non-cholinergic, non-adrenergic tonic component of the contractile responses.
豚鼠回肠纵肌层对以5 Hz或30 Hz频率施加的40秒电场刺激（0.8毫秒，20伏）的收缩反应包括快速的相性收缩，随后是低振幅的紧张性成分。阿托品（3微摩尔）和哌唑嗪（1微摩尔）显著降低了相性收缩的幅度，对紧张性成分的影响较小。SC 19220（50微摩尔）进一步降低了快速和紧张性收缩，对紧张性成分的抑制作用更为明显。提示电刺激过程中释放的前列腺素可能参与了收缩反应的非胆碱能、非肾上腺素能紧张性成分。
