Krempski James Walter, Warren Christopher, Han Xiaorui, Zhang Wenming, He Ziyuan, Lejeune Stéphanie, Nadeau Kari
Sean N. Parker Center for Allergy and Asthma Research, Stanford University, Stanford, CA, USA.
Sean N. Parker Center for Allergy and Asthma Research, Stanford University, Stanford, CA, USA.
Immunol Allergy Clin North Am. 2021 May;41(2):143-163. doi: 10.1016/j.iac.2021.01.003.
Food allergies have been rising in prevalence since the 1990s, imposing substantial physical, psychosocial, and economic burdens on affected patients and their families. Until recently, the only therapy for food allergy was strict avoidance of the allergenic food. Recent advances in translational studies, however, have led to insights into allergic sensitization and tolerance. This article provides an overview of cutting-edge research into food allergy and immune tolerance mechanisms utilizing mouse models, human studies, and systems biology approaches. This research is being translated and implemented in the clinical setting to improve diagnosis and reduce food allergy's public health burden.
自20世纪90年代以来，食物过敏的患病率一直在上升，给受影响的患者及其家庭带来了巨大的身体、心理社会和经济负担。直到最近，食物过敏的唯一治疗方法是严格避免食用致敏食物。然而，转化研究的最新进展使人们对过敏致敏和耐受性有了深入了解。本文概述了利用小鼠模型、人体研究和系统生物学方法对食物过敏和免疫耐受机制的前沿研究。这项研究正在临床环境中进行转化和应用，以改善诊断并减轻食物过敏对公共卫生的负担。
