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食物过敏患者的表型。

The Phenotype of the Food-Allergic Patient.

机构信息

Division of Allergy and Clinical Immunology, Henry Ford Health System, 1 Ford Place, Detroit, MI 48202, USA.

Division of Allergy and Clinical Immunology, Henry Ford Health System, 1 Ford Place, Detroit, MI 48202, USA.

出版信息

Immunol Allergy Clin North Am. 2021 May;41(2):165-175. doi: 10.1016/j.iac.2021.01.001. Epub 2021 Mar 26.

DOI:10.1016/j.iac.2021.01.001
PMID:33863477
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8054921/
Abstract

Food allergy's increasing prevalence across the globe has initiated research into risk factors associated with the disease and coexistence with other allergic diseases. Longitudinal birth cohorts have identified food allergy phenotypes of patients based on genetic background, racial diversity, and environmental factors. Identifying food sensitization patterns and coexistence of other allergic diseases allows physicians to provide appropriate care for food allergy and personalized anticipatory guidance for the appearance of other allergic diseases. The authors seek to detail key findings of 4 longitudinal allergy birth cohorts that investigate food allergy and other allergic diseases to further characterize food allergy phenotypes.

摘要

全球范围内食物过敏的患病率不断增加,促使人们对与该疾病相关的风险因素以及与其他过敏性疾病的共存关系展开研究。纵向出生队列研究根据遗传背景、种族多样性和环境因素确定了患者的食物过敏表型。确定食物致敏模式和其他过敏性疾病的共存情况,可使医生为食物过敏提供适当的护理,并为其他过敏性疾病的出现提供个性化的预期指导。作者旨在详细介绍 4 项研究食物过敏和其他过敏性疾病的纵向过敏出生队列的主要发现,以进一步描述食物过敏表型。

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Immunol Allergy Clin North Am. 2021 May;41(2):165-175. doi: 10.1016/j.iac.2021.01.001. Epub 2021 Mar 26.
2
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Food allergy phenotypes: The key to personalized therapy.食物过敏表型:个性化治疗的关键。
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本文引用的文献

1
Identification of two early life eczema and non-eczema phenotypes with high risk for asthma development.鉴定具有高哮喘发展风险的两种早期生命特应性皮炎和非特应性皮炎表型。
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Genome-wide association study of maternal genetic effects and parent-of-origin effects on food allergy.母亲遗传效应和印记效应与食物过敏的全基因组关联研究。
Medicine (Baltimore). 2018 Mar;97(9):e0043. doi: 10.1097/MD.0000000000010043.
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The Genetics of Food Allergy.食物过敏的遗传学。
Curr Allergy Asthma Rep. 2018 Jan 26;18(1):2. doi: 10.1007/s11882-018-0756-z.
4
Food allergy: A review and update on epidemiology, pathogenesis, diagnosis, prevention, and management.食物过敏:流行病学、发病机制、诊断、预防和管理的综述和更新。
J Allergy Clin Immunol. 2018 Jan;141(1):41-58. doi: 10.1016/j.jaci.2017.11.003. Epub 2017 Nov 21.
5
Food Allergy Is an Important Risk Factor for Childhood Asthma, Irrespective of Whether It Resolves.食物过敏是儿童哮喘的一个重要危险因素,无论其是否得到解决。
J Allergy Clin Immunol Pract. 2018 Jul-Aug;6(4):1336-1341.e3. doi: 10.1016/j.jaip.2017.10.019. Epub 2017 Nov 15.
6
Phenotypes of Atopic Dermatitis Depending on the Timing of Onset and Progression in Childhood.儿童特应性皮炎的表型取决于发病时间和病程进展情况。
JAMA Pediatr. 2017 Jul 1;171(7):655-662. doi: 10.1001/jamapediatrics.2017.0556.
7
An update on the impact of food allergy on anxiety and quality of life.食物过敏对焦虑和生活质量影响的最新情况
Curr Opin Pediatr. 2017 Aug;29(4):497-502. doi: 10.1097/MOP.0000000000000509.
8
Latent class analysis reveals clinically relevant atopy phenotypes in 2 birth cohorts.潜类分析揭示了 2 个出生队列中具有临床意义的特应性表型。
J Allergy Clin Immunol. 2017 Jun;139(6):1935-1945.e12. doi: 10.1016/j.jaci.2016.08.046. Epub 2016 Oct 19.
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Randomized Trial of Peanut Consumption in Infants at Risk for Peanut Allergy.对有花生过敏风险婴儿食用花生的随机试验。
N Engl J Med. 2016 Jul 28;375(4):398. doi: 10.1056/NEJMx150044.
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The march from early life food sensitization to allergic disease: a systematic review and meta-analyses of birth cohort studies.从生命早期食物致敏到过敏性疾病的进展:出生队列研究的系统评价和荟萃分析
Allergy. 2016 Jan;71(1):77-89. doi: 10.1111/all.12784. Epub 2015 Nov 4.