Division of Asthma Research, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati, 3333 Burnet Avenue, Cincinnati, OH 45229-3026, USA.
Division of Asthma Research, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati, 3333 Burnet Avenue, Cincinnati, OH 45229-3026, USA.
Immunol Allergy Clin North Am. 2021 May;41(2):301-319. doi: 10.1016/j.iac.2021.01.010. Epub 2021 Mar 26.
The risk factors for food allergy (FA) include both genetic variants and environmental factors. Advances using both candidate-gene association studies and genome-wide approaches have led to the identification of FA-associated genes involved in immune responses and skin barrier functions. Epigenetic changes have also been associated with the risk of FA. In this chapter, we outline current understanding of the genetics, epigenetics and the interplay with environmental risk factors associated with FA. Future studies of gene-environment interactions, gene-gene interactions, and multi-omics integration may help shed light on the mechanisms of FA, and lead to improved diagnostic and treatment strategies.
食物过敏（FA）的危险因素包括遗传变异和环境因素。候选基因关联研究和全基因组方法的进展，已经确定了与免疫反应和皮肤屏障功能相关的 FA 相关基因。表观遗传变化也与 FA 的风险相关。在本章中，我们概述了与 FA 相关的遗传学、表观遗传学以及与环境危险因素相互作用的当前认识。未来对基因-环境相互作用、基因-基因相互作用以及多组学整合的研究，可能有助于阐明 FA 的机制，并为改善诊断和治疗策略提供依据。
