Department of Neurosurgery, West China Hospital, Chengdu, Sichuan Province, PR China.
Department of Neurosurgery, West China Hospital, Chengdu, Sichuan Province, PR China.
J Clin Neurosci. 2021 May;87:59-65. doi: 10.1016/j.jocn.2021.02.014. Epub 2021 Mar 11.
This study aimed to assess the prevalence of developmental venous anomaly (DVA) in patients with thalamic glioma. Furthermore, we explored the association between DVA and some important biomarkers, such as IDH1 mutation, and H3K27M mutation.
Patients who received tumor resection in West China Hospital between August 2009 and October 2017 were enrolled. Propensity score matching was conducted based on a logistic regression model and 1:1 matching for case and control was used to generate a new cohort from patients with meningioma. Chi-square test, t-test, univariate and multivariate analyses were employed to assess the prevalence of DVA in thalamic glioma and meningioma and to identify risk factors associated with DVA.
Ninety-nine patients with thalamic glioma were enrolled in the current study (male, n = 54; female, n = 45). The mean age was 42.9 ± 15.3 years old. We identified a higher prevalence of DVA in 99 patients with thalamic glioma when compared with 99 patients with meningioma (18.18% vs. 7.07%), which was slightly lower than the prevalence of DVA in glioma reported in previous studies. Furthermore, the distribution of gender, age, and tumor grade in DVA did not reach statistical significance. Chi-square test, univariate and multivariate analyses showed that IDH1 mutation, ATRX mutation, MGMT promoter methylation, p53 mutation, MMP9, EGFR, and Top II positive expression, TERT mutation, and H3K27M mutation were not associated with the development of DVA in thalamic glioma.
A higher prevalence of DVA was found in thalamic glioma compared with meningioma.
本研究旨在评估伴有丘脑胶质瘤患者中发育性静脉异常（DVA）的发生率。此外，我们还探讨了 DVA 与一些重要生物标志物（如 IDH1 突变和 H3K27M 突变）之间的关系。
本研究纳入了 2009 年 8 月至 2017 年 10 月期间在华西医院接受肿瘤切除术的患者。基于逻辑回归模型进行倾向评分匹配，并对脑膜瘤患者进行 1:1 匹配以生成新的队列。采用卡方检验、t 检验、单因素和多因素分析来评估丘脑胶质瘤和脑膜瘤中 DVA 的发生率，并确定与 DVA 相关的危险因素。
本研究共纳入了 99 例丘脑胶质瘤患者（男性 n=54，女性 n=45）。患者的平均年龄为 42.9±15.3 岁。与 99 例脑膜瘤患者相比，我们发现 99 例丘脑胶质瘤患者中 DVA 的发生率更高（18.18%比 7.07%），略低于以往研究报道的胶质瘤中 DVA 的发生率。此外，DVA 组在性别、年龄和肿瘤分级方面的分布差异无统计学意义。卡方检验、单因素和多因素分析表明，IDH1 突变、ATRX 突变、MGMT 启动子甲基化、p53 突变、MMP9、EGFR 和 Top II 阳性表达、TERT 突变和 H3K27M 突变与丘脑胶质瘤中 DVA 的发生无关。
与脑膜瘤相比，丘脑胶质瘤中 DVA 的发生率更高。
