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准分子激光在经皮冠状动脉介入治疗中的应用:在一所大学教学医院的适应证、手术特点、并发症及结果。

Contemporary use of excimer laser in percutaneous coronary intervention with indications, procedural characteristics, complications and outcomes in a university teaching hospital.

机构信息

Department of interventional cardiology, Queen Elizabeth Hospital Birmingham, Birmingham, UK.

Institute of Cardiovascular Sciences, University of Birmingham, Birmingham, UK.

出版信息

Open Heart. 2021 Apr;8(1). doi: 10.1136/openhrt-2020-001522.

Abstract

BACKGROUND

Excimer laser coronary atherectomy (ELCA) can be used as an adjunctive percutaneous coronary intervention treatment for challenging, heavily calcified lesions. Although previous studies have documented high rates of complication and restenosis, these predate the introduction of the smaller 0.9 mm laser catheter. As the coronary complexity has increased, there has been a renewed interest in the ELCA. This study investigates the indications, procedural characteristics, complications and outcomes of ELCA in a contemporary coronary interventional practice.

METHODS

This single-centre study retrospectively analysed 50 patients treated with ELCA between January 2013 and January 2019.

RESULTS

Patients had a mean age of 67.9±11.4 years with a male predominance (65.3%). 25 (50%) cases were performed in patients with stable angina. Failure to deliver the smallest available balloon/microcatheter was the most frequent indication in 32 (64%) cases for ELCA use. 30 (60%) of the procedures were performed via radial access. The 0.9 mm X-80 catheter was used in 41 (82%) of cases, delivering on average 9000±3929 pulses. ELCA-related complications included 2 coronary dissections and 1 perforation, all of which were covered with stents. No major complications could be directly attributed to the use of ELCA. There was one death and one case of stent thrombosis within 30 days of the procedure.

CONCLUSION

ELCA can be performed safely via the radial approach with a 0.9 mm catheter with a high success rate by suitably trained operators. The low procedure-related complications with contemporary techniques make this a very useful tool for complex coronary interventions, especially for difficult to dilate lesions and chronic total occlusion vessels.

摘要

背景

准分子激光冠状动脉斑块切除术(ELCA)可作为经皮冠状动脉介入治疗的辅助手段,用于治疗有挑战性的严重钙化病变。尽管先前的研究已经记录了高并发症和再狭窄率,但这些都早于更小的 0.9mm 激光导管的引入。随着冠状动脉复杂性的增加,ELCA 再次受到关注。本研究调查了在当代冠状动脉介入治疗实践中 ELCA 的适应证、手术特点、并发症和结局。

方法

这项单中心研究回顾性分析了 2013 年 1 月至 2019 年 1 月期间接受 ELCA 治疗的 50 例患者。

结果

患者平均年龄为 67.9±11.4 岁,男性居多(65.3%)。25 例(50%)患者因稳定型心绞痛而行 ELCA。在 32 例(64%)需要行 ELCA 的病例中,无法输送最小可用的球囊/微导管是最常见的适应证。30 例(60%)手术经桡动脉入路进行。41 例(82%)采用 0.9mm X-80 导管,平均输送 9000±3929 个脉冲。ELCA 相关并发症包括 2 例冠状动脉夹层和 1 例穿孔,均用支架覆盖。没有主要并发症可直接归因于 ELCA 的使用。术后 30 天内有 1 例死亡和 1 例支架血栓形成。

结论

ELCA 可由经过适当培训的操作者经桡动脉途径安全使用 0.9mm 导管进行,成功率高。现代技术使该方法相关并发症较低,使其成为复杂冠状动脉介入治疗的非常有用的工具,尤其是对于难以扩张的病变和慢性完全闭塞血管。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/21af/8055138/6d64f08d976e/openhrt-2020-001522f01.jpg

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