Department of Neuroscience "Rita Levi Montalcini", University of Torino, Via Cherasco 15, 10126, Turin, Italy.
Department of Neuroscience, Brighton & Sussex Medical School, University of Sussex, Brighton, East Sussex, UK.
Neurol Sci. 2021 Jul;42(7):2619-2623. doi: 10.1007/s10072-021-05233-y. Epub 2021 Apr 16.
We report here the first case of a young individual otherwise healthy, who presented with frequent focal seizures with impaired awareness as a possible long-term complication of severe acute respiratory syndrome coronavirus-2 infection. Seizures were documented by electroencephalography and responded clinically and neuro-physiologically to antiseizure therapy. The patient underwent an extensive investigation including cerebrospinal fluid examination, conventional and quantitative brain magnetic resonance imaging, and 18-FDG positron emission tomography. Beyond the clinical interest, this case contributes to clarify the possible pathways by which SARS-CoV-2 may enter the central nervous system and cause long-term neurological complications.
我们在此报告首例年轻个体病例，该个体 otherwise healthy，表现为频繁的局灶性意识障碍性癫痫发作，这可能是严重急性呼吸综合征冠状病毒 2 感染的长期并发症。癫痫发作通过脑电图记录，并通过抗癫痫治疗在临床和神经生理学上得到缓解。患者接受了广泛的检查，包括脑脊液检查、常规和定量脑磁共振成像以及 18-FDG 正电子发射断层扫描。除了临床意义外，该病例还有助于阐明 SARS-CoV-2 可能进入中枢神经系统并导致长期神经并发症的可能途径。
