Letiagin V P, Sokolova I G, Kondrat'eva A P, Ivanov V M
Med Radiol (Mosk). 1988 Jun;33(6):41-4.
The paper is devoted to the clinical characterization and results of therapy of 45 patients with locally advanced, primary inoperable cancer. Most of the women were at the age of 40-60, of them 64% had preserved menstrual ovarian function. Multimodality therapy included radiation therapy combined with chemotherapy (UAM and CMF schemes). The breast and all zones of regional metastasis were irradiated at a single focal dose of 2 Gy, the total focal doses were 67-70 Gy to the breast, 50 Gy to the axillary and supra- and subclavicular areas, and 34-40 Gy to the parasternal area. This therapy was followed by radical mastectomy on 30 patients. A degree of expression of a clinical effect and therapeutic pathomorphosis was emphasized. Proceeding from 2-year long-term results, multimodality therapy including surgical intervention was found appropriate.
本文致力于45例局部晚期、原发性不可手术切除癌症患者的临床特征及治疗结果。大多数女性年龄在40至60岁之间，其中64%保留了卵巢月经功能。多模式治疗包括放射治疗联合化疗（UAM和CMF方案）。对乳房及区域转移的所有区域进行照射，单次局部剂量为2 Gy，乳房的总局部剂量为67至70 Gy，腋窝及锁骨上下区域为50 Gy，胸骨旁区域为34至40 Gy。30例患者在该治疗后接受了根治性乳房切除术。强调了临床疗效和治疗病理形态变化的表达程度。从2年的长期结果来看，包括手术干预的多模式治疗是合适的。
