维生素 D、骨矿物质密度和血清 IGF-1 水平在非运动性脑瘫儿童中的变化。

Vitamin D, Bone Mineral Density and Serum IGF-1 Level in Non-ambulatory Children With Cerebral Palsy.

机构信息

Department of Pediatrics, Pt. BD Sharma PGIMS, Rohtak, Haryana.

Department of Pediatrics, Pt. BD Sharma PGIMS, Rohtak, Haryana. Correspondence to: Dr Kapil Bhalla, Department of Pediatrics, Pandit Bhagwat Dayal Sharma Post Graduate Institute of Medical Sciences, Rohtak 124 001, Haryana.

出版信息

Indian Pediatr. 2021 Sep 15;58(9):836-838. Epub 2021 Apr 17.

PMID:33864451

Abstract

OBJECTIVES

To compare serum 25-hydroxy vitamin D (25-OHD) status, bone mineral density and Insulin-like growth factor (IGF-1) level among children with cerebral palsy (CP) aged 1 to 8 years with age- and gender-matched controls.

METHODS

A cross-sectional study enrolled 30 children in each group: CP with epilepsy, CP without epilepsy, and healthy controls. Bone mineral density (BMD), serum 25-OHD levels, and serum insulin like growth factor (IGF)-1 levels were measured.

RESULTS

z-scores of BMD [-1.80 (1.03), -2.12 (0.85) vs -1.40 (0.90); P<0.01], 25-OHD levels [19.26 (8.28), 20.59 (8.92) Vs 26.79 (12.76) ng/mL; P<0.01] and IGF-1 levels [20.90 (6.42), 23.37 (8.11) vs 31.77 (11.21) ng/mL; P<0.01] were significantly low among children with CP with epilepsy, CP without epilepsy when compared to controls.

CONCLUSIONS

Children with CP with or without comorbid epilepsy were prone to vitamin D deficiency, low bone mineral density and growth hormone axis suppression with low IGF-1 levels.

摘要

目的

比较 1 至 8 岁脑瘫（CP）患儿与年龄和性别匹配的对照组之间血清 25-羟维生素 D（25-OHD）水平、骨密度和胰岛素样生长因子（IGF-1）水平。

方法

一项横断面研究纳入每组 30 名儿童：伴癫痫的 CP、无癫痫的 CP 和健康对照组。测量骨矿物质密度（BMD）、血清 25-OHD 水平和血清胰岛素样生长因子（IGF）-1 水平。

结果

BMD 的 z 评分[-1.80（1.03），-2.12（0.85）vs -1.40（0.90）；P<0.01]、25-OHD 水平[19.26（8.28），20.59（8.92）Vs 26.79（12.76）ng/mL；P<0.01]和 IGF-1 水平[20.90（6.42），23.37（8.11）vs 31.77（11.21）ng/mL；P<0.01]在伴癫痫的 CP 和无癫痫的 CP 患儿中均显著低于对照组。