Department of Infectious Diseases, Inselspital, University Hospital Bern, Bern, Switzerland; Ente Ospedaliero Cantonale, Division of Infectious Diseases, Regional Hospital Lugano, Lugano, Switzerland.
Department of Infectious Diseases, Inselspital, University Hospital Bern, Bern, Switzerland; Infection Control Programme, University of Geneva Hospitals and Faculty of Medicine, Geneva, Switzerland; UMR 1137 IAME Team 5 DeSCID: Decision Sciences in Infectious Diseases, Control and Care Inserm/University Paris Diderot, Sorbonne Paris Cité, Paris, France.
J Hosp Infect. 2021 Aug;114:175-179. doi: 10.1016/j.jhin.2021.04.006. Epub 2021 Apr 15.
There is limited and conflicting information on the prevalence of contamination of haematopoietic stem and progenitor cell products (HPCPs), and their optimal management remains unclear. The authors reviewed the microbial surveillance data of HPCPs collected between January 2002 and December 2019 for autologous transplantation at the study institution to determine the prevalence of microbial contamination and the potential infectious complications among recipients. Among 3935 HPCPs, 25 (0.6%) were contaminated. Ultimately, 22 patients received contaminated grafts, with pre-emptive antimicrobial therapy initiated in six of these patients. No patients developed subsequent infectious complications. These data suggest that microbial contamination of autologous HPCPs and associated adverse outcomes are rare.
有关造血干细胞和祖细胞产品（HPCPs）污染的流行率的信息有限且存在冲突，其最佳管理方法仍不清楚。作者回顾了研究机构在 2002 年 1 月至 2019 年 12 月期间为自体移植而收集的 HPCPs 的微生物监测数据，以确定受者中微生物污染的流行率和潜在的感染并发症。在 3935 份 HPCPs 中，有 25 份（0.6%）受到污染。最终，有 22 名患者接受了污染的移植物，其中 6 名患者预防性使用了抗菌药物。没有患者发生后续感染并发症。这些数据表明，自体 HPCPs 的微生物污染及其相关不良后果很少见。
