Green Rachel, Abe Caroline, Denney David A, Zhang Rong, Doyle Alexander, Gadelmola Kareem, Cullum C Munro, Simon Jessica, Neaves Stephanie, Perven Ghazala, Dieppa Marisara, Hays Ryan, Agostini Mark, Ding Kan
Department of Neurology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, TX, 75390, USA.
Department of Psychiatry, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, TX, 75390, USA.
Epilepsy Res. 2021 Jul;173:106639. doi: 10.1016/j.eplepsyres.2021.106639. Epub 2021 Apr 9.
People with epilepsy (PWE) tend to have sedentary lifestyles which may predispose them to a lower perceived quality of life (QOL). Moreover, the relationship between physical activity (PA) and QOL in populations of PWE with high disease burden has been under-studied. The goal of this study was to evaluate PA level and its impact on health-related QOL in PWE who were admitted to Level-4 epilepsy monitoring units (EMU).
In this prospective observational study, 200 patients from two EMUs in Dallas, Texas completed the following standard surveys: Rapid Assessment of Physical Activity (RAPA), the Quality of Life in Epilepsy (QOLIE-31), Patient Health Questionnaire-9 (PHQ-9), and Generalized Anxiety Disorder 7-item (GAD-7) questionnaire. Information on self-reported epilepsy history, severity of disease, and socioeconomic status were also collected. The diagnosis of epilepsy was confirmed by video-EEG monitoring.
Among the 200 who completed the survey, 113 had a diagnosis of epilepsy and 109 of them completed the RAPA. Ninety-two (84 %) of these PWE reported a sedentary level of physical activity (RAPA < 6) and 16 % reported an active level (RAPA ≥ 6). Self-reported QOL was slightly higher in PWE with an active level of PA compared to PWE with a sedentary level of PA (63.8 ± 15.0 vs 53.7 ± 17.9, p = 0.07), even though there was no difference in the severity of self-reported mood symptoms. After controlling for employment and seizure frequency, physical activity level measured by RAPA score was also positively related to QOL (r = 0.39, p = 0.01) and negatively correlated with anxiety symptoms (r = -0.28, p = 0.02) and depression symptoms (r = -0.25, p = 0.04).
The majority of PWE in this survey reported sedentary lifestyles despite most of them being young to middle-aged adults. Higher PA level was associated with fewer self-reported mood symptoms and higher QOL. In conjunction with the literature, these results suggest that PWE with a wide range of disease burden should be encouraged to participate in regular exercise to potentially improve QOL.
癫痫患者（PWE）往往有久坐不动的生活方式，这可能使他们的生活质量（QOL）感知较低。此外，在疾病负担较重的癫痫患者群体中，身体活动（PA）与生活质量之间的关系研究较少。本研究的目的是评估入住四级癫痫监测单元（EMU）的癫痫患者的身体活动水平及其对健康相关生活质量的影响。
在这项前瞻性观察研究中，来自德克萨斯州达拉斯市两个癫痫监测单元的200名患者完成了以下标准调查：身体活动快速评估（RAPA）、癫痫生活质量（QOLIE - 31）、患者健康问卷 - 9（PHQ - 9）和广泛性焦虑障碍7项（GAD - 7）问卷。还收集了自我报告的癫痫病史、疾病严重程度和社会经济状况的信息。癫痫诊断通过视频脑电图监测得以确认。
在完成调查的200人中，113人被诊断为癫痫，其中109人完成了RAPA调查。这些癫痫患者中，92人（84%）报告身体活动水平为久坐不动（RAPA < 6），16%报告身体活动水平活跃（RAPA≥6）。与久坐不动的癫痫患者相比，身体活动水平活跃的癫痫患者自我报告的生活质量略高（63.8±15.0对53.7±17.9，p = 0.07），尽管自我报告的情绪症状严重程度没有差异。在控制就业和癫痫发作频率后，通过RAPA评分测量的身体活动水平也与生活质量呈正相关（r = 0.39，p = 0.01），与焦虑症状呈负相关（r = -0.28，p = 0.02），与抑郁症状呈负相关（r = -0.25，p = 0.04）。
尽管本次调查中的大多数癫痫患者为中青年成年人，但他们大多报告有久坐不动的生活方式。较高的身体活动水平与较少的自我报告情绪症状和较高的生活质量相关。结合文献来看，这些结果表明，应鼓励疾病负担各异的癫痫患者参与定期锻炼，以潜在地改善生活质量。
