Department of Cell Biology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT, 06520-8002, USA.
Howard Hughes Medical Institute and Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, MA, 02115, USA.
Curr Opin Cell Biol. 2021 Aug;71:130-138. doi: 10.1016/j.ceb.2021.02.010. Epub 2021 Apr 14.
Specificity and sensitivity in biochemical reactions can be achieved through regulation of equilibrium binding affinity or through proofreading mechanisms that allow for the dissociation of unwanted intermediates. In this essay, we aim to provide our perspectives on how the concept of kinetic proofreading might apply in the context of cargo sorting in clathrin-mediated endocytosis.
生化反应的特异性和灵敏度可以通过调节平衡结合亲和力或通过允许不需要的中间产物解离的校对机制来实现。在本文中，我们旨在提供我们对动力学校对概念如何应用于网格蛋白介导的胞吞作用中货物分拣的观点。
