Zhan Zhiqiang, Fei Zhenghua, Xu Bingying, Zhong Dian, Dong Dapeng
Clin Lab. 2021 Apr 1;67(4). doi: 10.7754/Clin.Lab.2020.200812.
Red blood cell distribution width (RDW) is a parameter reported in blood routine examination, and has been reported as an inflammatory biomarker. The objective of this study was to investigate the significance of RDW in NSCLC patients with EGFR mutations.
The clinical data of 102 patients with NSCLC who underwent radical resection surgery in the First Affiliated Hospital of Wenzhou Medical University from December 2012 to November 2017 were collected. Kaplan-Meier survival analysis and Cox proportional hazard models were used to examine the effect of RDW on survival.
The RDW levels were divided into two groups: high RDW (≥ 13.1%), n = 47 vs. low RDW, n = 55 (< 13.1%). Univariate analysis showed that there were significant associations of high RDW values with smoking history and brain metastasis. Forty-seven patients with elevated RDW levels had shorter progression-free survival (PFS) than 55 patients with normal RDW levels (264 vs. 310 days, p = 0.039).
RDW is associated with several factors that reflect inflammation and malnutrition in lung cancer patients. Moreover, high levels of RDW are associated with poor survival.
红细胞分布宽度（RDW）是血常规检查中报告的一项参数，已被报道为一种炎症生物标志物。本研究的目的是探讨RDW在EGFR突变的非小细胞肺癌（NSCLC）患者中的意义。
收集了2012年12月至2017年11月在温州医科大学附属第一医院接受根治性手术的102例NSCLC患者的临床资料。采用Kaplan-Meier生存分析和Cox比例风险模型来检验RDW对生存的影响。
将RDW水平分为两组：高RDW（≥13.1%），n = 47与低RDW，n = 55（<13.1%）。单因素分析显示，高RDW值与吸烟史和脑转移存在显著关联。47例RDW水平升高的患者的无进展生存期（PFS）短于55例RDW水平正常的患者（264天对310天，p = 0.039）。
RDW与反映肺癌患者炎症和营养不良的几个因素相关。此外，高水平的RDW与较差的生存率相关。
