Department of Clinical Laboratory, Chongqing Hospital of Jiangsu Province Hospital, The People's Hospital of Qijiang District, Chongqing, China.
Department of Hepatobiliary Surgery, Chongqing Hospital of Jiangsu Province Hospital, The People's Hospital of Qijiang District, Chongqing, China.
Medicine (Baltimore). 2024 Jun 14;103(24):e38475. doi: 10.1097/MD.0000000000038475.
This study examines the relationship between red blood cell distribution width (RDW) and the prognosis of patients undergoing hepatectomy for hepatocellular carcinoma (HCC). Additionally, it explores the potential effect of RDW for the early identification of high-risk patients after surgery, advocating for timely interventions to improve outcomes. A comprehensive literature search was conducted on May 16, 2022, across PubMed (23 studies), Embase (45 studies), the Cochrane Library (1 study), and CNKI (17 studies), resulting in 6 relevant articles after screening. This analysis primarily focused on the postoperative outcomes of patients. Hazard ratios (HRs) and 95% confidence intervals (CIs) were pooled to assess prognosis, with survival indicators including overall survival (OS) and disease-free survival (DFS). All 6 studies reported on OS, and 2 addressed DFS. A total of 1645 patients from 6 studies were included. The pooled analysis revealed that RDW is an independent prognostic factor for both OS (HR = 1.50, I² = 84%, 95% CI = 1.23-1.77, P < .01) and DFS (HR = 2.06, I² = 15%, 95% CI = 1.51-2.82, P < .01). Patients in the high RDW group exhibited significantly poorer OS and DFS compared to those in the low RDW group. RDW is a prognostic factor for HCC patients after surgery. Elevated RDW levels are associated with a poorer prognosis, adversely affecting both OS and DFS. RDW may serve as a valuable marker for stratifying risk and guiding intervention strategies in the postoperative management of HCC patients.
这项研究探讨了红细胞分布宽度（RDW）与接受肝细胞癌（HCC）肝切除术患者预后之间的关系。此外，它还探讨了 RDW 用于早期识别手术后高危患者的潜在效果，提倡及时干预以改善结果。于 2022 年 5 月 16 日，通过对 PubMed（23 项研究）、Embase（45 项研究）、Cochrane 图书馆（1 项研究）和 CNKI（17 项研究）进行全面文献检索，筛选后得到 6 项相关文章。该分析主要侧重于患者的术后结果。风险比（HRs）和 95%置信区间（CIs）被汇总以评估预后，生存指标包括总生存期（OS）和无病生存期（DFS）。6 项研究均报告了 OS，2 项研究报告了 DFS。共有来自 6 项研究的 1645 名患者纳入了汇总分析。汇总分析显示，RDW 是 OS（HR=1.50，I²=84%，95%CI=1.23-1.77，P<.01）和 DFS（HR=2.06，I²=15%，95%CI=1.51-2.82，P<.01）的独立预后因素。RDW 较高组的患者 OS 和 DFS 明显差于 RDW 较低组的患者。RDW 是 HCC 患者手术后的预后因素。RDW 升高与预后较差相关，对 OS 和 DFS 均有不利影响。RDW 可能是 HCC 患者术后分层风险和指导干预策略的有价值标志物。
