Yin Hongling, Zhang Qian, Zhou Qunzhi, Xia Chengwan, Pu Yumei, Wang Yuxin
Clin Lab. 2021 Apr 1;67(4). doi: 10.7754/Clin.Lab.2020.200723.
Early diagnosis of cancer is related to a good prognosis. Noninvasive methods of body fluid diagnosis are receiving more and more attention. Many studies have shown that exosomal miRNAs in body fluids may be potential biomarkers. Therefore, we conducted a meta-analysis to assess the overall diagnostic value of liquid exosomal miRNAs for cancer.
Relevant research was retrieved from multiple electronic databases. The research quality was evaluated based on the QUADAS-2 scale in Review Manager 5.3. Diagnostic value was evaluated by data analysis using Stata 16.0, and Meta-DiSc 1.4.
The meta-analysis included 23 articles and 79 research units. The pooled sensitivity was 0.74, specificity was 0.78, the diagnostic likelihood ratio positive was 3.55, the diagnostic likelihood ratio negative was 0.29, diagnostic OR was 14.26, and area under the curve was 0.8621. These results provide evidence for liquid exosomal miRNAs as potential biomarkers.
Liquid exosomal miRNAs are potential biomarkers for cancer diagnosis. In particular, diagnosis based on multiple miRNAs is more valuable than a single miRNA.
癌症的早期诊断与良好的预后相关。体液诊断的非侵入性方法正受到越来越多的关注。许多研究表明，体液中的外泌体微小RNA（miRNAs）可能是潜在的生物标志物。因此，我们进行了一项荟萃分析，以评估液体外泌体miRNAs对癌症的总体诊断价值。
从多个电子数据库中检索相关研究。根据Review Manager 5.3中的QUADAS-2量表评估研究质量。使用Stata 16.0和Meta-DiSc 1.4通过数据分析评估诊断价值。
荟萃分析纳入了23篇文章和79个研究单位。合并敏感性为0.74，特异性为0.78，诊断阳性似然比为3.55，诊断阴性似然比为0.29，诊断比值比为14.26，曲线下面积为0.8621。这些结果为液体外泌体miRNAs作为潜在生物标志物提供了证据。
液体外泌体miRNAs是癌症诊断的潜在生物标志物。特别是，基于多种miRNAs的诊断比单一miRNA更有价值。
