曲霉定植中交链格孢菌引起的变应性支气管肺曲霉菌病 1 例报告
A case report of allergic bronchopulmonary mycosis caused by Alternaria alternata in colonization of Aspergillus.
机构信息
Division of Pulmonology, Department of Internal Medicine, Hanyang University College of Medicine, Seoul, Republic of Korea.
Department of Pathology, Hanyang University Guri Hospital, Hanyang University College of Medicine, Seoul, Republic of Korea.
出版信息
Asian Pac J Allergy Immunol. 2024 Sep;42(3):290-293. doi: 10.12932/AP-101020-0981.
BACKGROUND
Allergic bronchopulmonary aspergillosis (ABPA) is a pulmonary disease caused by a complex hypersensitivity reaction to colonization of the airways with various fungi. ABPA caused by Alternaria alternata, other than Aspergillus spp., is named Allergic bronchopulmonary mycosis (ABPM).
OBJECTIVE
To describe the first case of ABPM caused by Alternaria alternata in East Asia.
METHODS
Case report.
RESULTS
A 58-year-old female visited our hospital due to an abnormal chest x-ray, following chest computed tomography (CT) revealed consolidation in the left lower lobe. On laboratory finding, eosinophil count and total IgE level were high. The skin prick test and specific IgE for Alternaria alternata were positive. After diagnosis of ABPM, the patient was treated with prednisolone without antifungal agents, and her chest image was much improved.
CONCLUSIONS
Aspergillus is most common etiology of allergic pulmonary disease, however, Alternaria should be considered even though positive culture of Aspergillus spp.
背景
变应性支气管肺曲霉病（ABPA）是一种由气道定植的各种真菌引起的复杂超敏反应导致的肺部疾病。除了曲霉菌属外，由链格孢菌引起的 ABPA 被命名为变应性支气管肺真菌病（ABPM）。
目的
描述东亚首例由链格孢菌引起的 ABPM。
方法
病例报告。
结果
一名 58 岁女性因胸片异常就诊，胸部 CT 显示左下肺实变。实验室检查发现，嗜酸性粒细胞计数和总 IgE 水平升高。变应原皮试和链格孢菌特异性 IgE 阳性。诊断为 ABPM 后，患者接受泼尼松龙治疗，未使用抗真菌药物，其胸部影像明显改善。
结论
曲霉菌是最常见的过敏性肺部疾病病原体，但即使曲霉菌属的培养结果为阳性，也应考虑链格孢菌。
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