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自体移植对斑驳病进行色素矫正。I. 手术步骤及临床发现。

Pigmentary correction of piebaldism by autografts. I. Procedures and clinical findings.

作者信息

Selmanowitz V J, Rabinowitz A D, Orentreich N, Wenk E

出版信息

J Dermatol Surg Oncol. 1977 Nov-Dec;3(6):615-22. doi: 10.1111/j.1524-4725.1977.tb00368.x.

DOI:10.1111/j.1524-4725.1977.tb00368.x
PMID:338655
Abstract

Full-thickness and epidermal autografts of normally pigmented skin were transplanted within hypopigmented areas in each of two patients with piebaldism. Full-thickness punch grafts 2 to 4 mm in size retained their pigmentation (donor dominance) and within 4 months pigment was found to have spread around them. Within a year, melanization covered roughly triple the diameter of the grafts (or 9 times their areas) and then came to a standstill. Epidermal grafts (about 12 mm in diameter) healed with no visible scars at either donor or recipient sites. These grafts, too, retained their pigmentation, but no pigment was seen to spread from them in 8 months of observation. Controls of hypopigmented, full-thickness autografts placed into comparable hypopigmented areas showed either no change or but slight pigmentation along the rim of the graft and no spread of pigment.

摘要

在两名斑驳病患者的色素减退区域内,移植了正常色素沉着皮肤的全层自体皮片和表皮自体皮片。2至4毫米大小的全层打孔移植皮片保持了其色素沉着(供体优势),并且在4个月内发现色素在其周围扩散。在一年内,黑素沉着覆盖的直径大约是移植皮片的三倍(或面积的9倍),然后停止。表皮移植皮片(直径约12毫米)在供体和受体部位均愈合且无可见疤痕。这些移植皮片也保持了其色素沉着,但在8个月的观察期内未发现色素从它们那里扩散。将色素减退的全层自体皮片置于类似的色素减退区域作为对照,结果显示要么没有变化,要么移植皮片边缘仅有轻微色素沉着,且色素没有扩散。

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J Dermatol Surg Oncol. 1977 Nov-Dec;3(6):615-22. doi: 10.1111/j.1524-4725.1977.tb00368.x.
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引用本文的文献

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Dominant negative and loss of function mutations of the c-kit (mast/stem cell growth factor receptor) proto-oncogene in human piebaldism.人类斑驳病中c-kit(肥大/干细胞生长因子受体)原癌基因的显性负性突变和功能丧失突变。
Am J Hum Genet. 1992 Feb;50(2):261-9.