颞骨纤维骨性隆起性病变：四例报告并文献复习。

Protuberant fibro-osseous lesion of the temporal bone: report of four cases and review of the literature.

机构信息

Service de Chirurgie Maxillo-faciale et Chirurgie Plastique, Hôpital Necker - Enfants Malades, Assistance Publique - Hôpitaux de Paris, Université de Paris, Paris, France; Service de Chirurgie Maxillo-faciale et Stomatologie, Hôpital Pitié-Salpêtrière, Assistance Publique - Hôpitaux de Paris, Sorbonne Université, Paris, France.

Service d'Anatomopathologie, Hôpital Cochin - Port-Royal, Assistance Publique - Hôpitaux de Paris, Université de Paris, Paris, France.

出版信息

Int J Oral Maxillofac Surg. 2021 Dec;50(12):1566-1570. doi: 10.1016/j.ijom.2021.03.002. Epub 2021 Apr 15.

DOI:10.1016/j.ijom.2021.03.002

PMID:33865660

Abstract

'Bullough lesions', also referred to as protuberant fibro-osseous lesions (PFOL), are rare temporal bone lesions initially described in 1999. Since only 12 cases have been reported, several key issues, such as their origin and recommended management strategies, remain unresolved. This article reports the largest cohort included in the literature to date, comprising four patients with PFOL. PFOL appears to be characterized by female and right-side predominance. These lesions were consistently located regarding the mastoid, generally diagnosed in early adulthood, without functional symptoms, and were always fibro-osseous. Invasive/malignant features were not found on imaging or histology. The main differential diagnosis was malignant low-grade parosteal osteosarcoma. Clinical examination and computed tomography images provided strong elements supporting the diagnosis of PFOL. Biopsy allowed molecular biology investigations (MDM2 and CDK4 amplification), in order to rule out low-grade parosteal osteosarcoma.

摘要

'Bullough 病变'，也称为外凸性纤维骨性病变（PFOL），是一种罕见的颞骨病变，最初于 1999 年描述。由于仅报道了 12 例病例，因此其起源和推荐的治疗策略等几个关键问题仍未得到解决。本文报道了迄今为止文献中包含的最大队列，包括 4 例 PFOL 患者。PFOL 似乎以女性和右侧优势为特征。这些病变通常位于乳突区，在成年早期被诊断出来，没有功能症状，且始终为纤维骨性。影像学或组织学均未发现侵袭性/恶性特征。主要的鉴别诊断是恶性低度骨旁骨肉瘤。临床检查和计算机断层扫描图像为 PFOL 的诊断提供了有力的依据。活检可进行分子生物学检查（MDM2 和 CDK4 扩增），以排除低度骨旁骨肉瘤。