在 COPD 患者运动期间，神经肌肉效率受损。
Neuromuscular efficiency is impaired during exercise in COPD patients.
机构信息
Laboratory of Physical Training Studies Applied to Health. Department of Physical Education, Federal University of Paraíba, João Pessoa, PB, Brazil; Associate Graduate Program in Physical Education UPE/UFPB, Brazil; CLINAR - Exercise Physiology, Brazil.
Laboratory of Physical Training Studies Applied to Health. Department of Physical Education, Federal University of Paraíba, João Pessoa, PB, Brazil; Associate Graduate Program in Physical Education UPE/UFPB, Brazil.
出版信息
Respir Physiol Neurobiol. 2021 Aug;290:103673. doi: 10.1016/j.resp.2021.103673. Epub 2021 Apr 16.
AIM
to analyze respiratory and peripheral neuromuscular efficiency during exercise in COPD.
METHODS
COPD patients (VEF = 39.25 ± 13.1 %) were paired with healthy subjects. It was performed cardiopulmonary exercise test with simultaneously electromyography (EMG). Respiratory neuromuscular efficiency was determined by relationship between tidal volume and diaphragm EMG. Peripheral neuromuscular efficiency was determined by relationship between power output and vastus lateralis EMG.
RESULTS
Healthy subjects presented higher respiratory neuromuscular efficiency at moderate, heavy and maximum exercise intensities compared to COPD (p < 0.05). Healthy subjects presented higher peripheral neuromuscular efficiency at light, moderate, heavy and maximum exercise intensities compared to COPD (p < 0.001). Dynamic hyperinflation presented correlation with respiratory and peripheral neuromuscular efficiency (r = -0.73 and r = -0.76, p < 0.001).
CONCLUSION
COPD patients have lower respiratory neuromuscular efficiency at moderate exercise intensity and lower peripheral neuromuscular efficiency at light exercise intensity. Dynamic hyperinflation affects respiratory and peripheral neuromuscular efficiency.
目的
分析 COPD 患者运动时的呼吸和周围神经肌肉效率。
方法
将 COPD 患者（VEF=39.25±13.1%）与健康受试者配对。进行心肺运动试验，同时进行肌电图（EMG）检测。通过潮气量与膈肌 EMG 的关系来确定呼吸神经肌肉效率。通过功率输出与股外侧肌 EMG 的关系来确定外周神经肌肉效率。
结果
与 COPD 患者相比，健康受试者在中等、大强度和最大运动强度时呼吸神经肌肉效率更高（p<0.05）。与 COPD 患者相比，健康受试者在轻、中、大强度和最大运动强度时外周神经肌肉效率更高（p<0.001）。动态过度充气与呼吸和外周神经肌肉效率呈负相关（r=-0.73 和 r=-0.76，p<0.001）。
结论
COPD 患者在中等运动强度时呼吸神经肌肉效率较低，在轻运动强度时外周神经肌肉效率较低。动态过度充气影响呼吸和外周神经肌肉效率。
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