基于血管内灌注的对比增强超声 LI-RADS 在肝细胞癌评估中的诊断性能。
Diagnostic performance of intravascular perfusion based contrast-enhanced ultrasound LI-RADS in the evaluation of hepatocellular carcinoma.
机构信息
Department of Ultrasound, The First Affiliated Hospital of Hainan Medical University, Haikou, China.
Department of Ultrasound, The Second Affiliated Hospital of Nanchang University, Nanchang, China.
出版信息
Clin Hemorheol Microcirc. 2021;78(4):429-437. doi: 10.3233/CH-211164.
BACKGROUND
The contrast-enhanced ultrasound (CEUS) liver imaging reporting and data system (LI-RADS) is a relative new algorithm for hepatocellular carcinoma (HCC) assessment.
OBJECTIVE
To validate the diagnostic efficiency of the intravascular perfusion based CEUS LI-RADS for HCC.
METHODS
Archives of 873 patients with focal liver lesions (FLLs) undergoing CEUS were reviewed, and target images were read by two sonologists independently according to the CEUS LI-RADS. The diagnostic performance was calculated and compared.
RESULTS
Assessment with reference to CEUS LI-RADS, 87 of 218 FLLs (39.9%) were categorized as LR-5, 131 of 218 FLLs (60.1%) were categorized as non-LR-5, 19 of 99 HCCs were categorized as non-LR-5, and 7 of 119 non-HCCs were categorized as LR-5. The sensitivity, specificity, AUROC, positive and negative predictive values of CEUS LI-RADS for diagnosing HCC were 80.81%(95%CI: 71.7%-88.0%), 94.1%(95%CI: 88.3%-97.6%), 0.87 (95%CI: 0.82-0.92), 91.9%(95%CI: 84.1%-96.7%), and 85.5%(95%CI: 78.3%-91.0%), respectively.
CONCLUSIONS
The diagnostic efficiency of the intravascular perfusion based CEUS LI-RADS for the evaluation of HCCs is very good.
背景
对比增强超声（CEUS）肝脏影像报告和数据系统（LI-RADS）是一种用于肝细胞癌（HCC）评估的相对较新的算法。
目的
验证基于血管内灌注的 CEUS LI-RADS 对 HCC 的诊断效能。
方法
回顾分析了 873 例接受 CEUS 检查的局灶性肝脏病变（FLL）患者的档案，由两名超声医师独立根据 CEUS LI-RADS 阅读靶图像。计算并比较了诊断性能。
结果
参照 CEUS LI-RADS 评估，218 个 FLL 中有 87 个（39.9%）被归类为 LR-5，218 个 FLL 中有 131 个（60.1%）被归类为非 LR-5，99 个 HCC 中有 19 个（19.2%）被归类为非 LR-5，119 个非 HCC 中有 7 个（6.7%）被归类为 LR-5。CEUS LI-RADS 诊断 HCC 的敏感性、特异性、AUROC、阳性和阴性预测值分别为 80.81%（95%CI：71.7%-88.0%）、94.1%（95%CI：88.3%-97.6%）、0.87（95%CI：0.82-0.92）、91.9%（95%CI：84.1%-96.7%）和 85.5%（95%CI：78.3%-91.0%）。
结论
基于血管内灌注的 CEUS LI-RADS 对 HCC 的评估具有很好的诊断效率。
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