Department of Neurosurgery of Wuhan Third Hospital.
Department of Surgery and Anesthesia, Taikang Tongji (Wuhan) Hospital, Wuhan.
J Craniofac Surg. 2021;32(8):e830-e833. doi: 10.1097/SCS.0000000000007683.
Cerebellar hemangioblastomas with pregnancy is rare, but coexistence of pregnancy and recurrent cerebellar hemangioblastomas is rather rare. And coexistence of other diseases during pregnancy usually leads to misdiagnosis because of pregnancy reaction. A 29-year-old woman, at the 8th week of pregnancy, complained of nausea, vomiting, and episodic posterior occipital pain and was misdiagnosed pregnancy reaction without any special treatment during her several visits to local hospital. The patient was diagnosed cerebellar hemangioblastomas 14 years ago, after surgery, she received regular re-examination without recurrence. At the 15th week of pregnancy, the situation of the patient got worse, and she was admitted to our hospital. Brain magnetic resonance imaging showed a lesion in cerebellum. It was considered to be cerebellar hemangioblastomas and was confirmed finally by postoperative pathological examination. In clinical practice, differential diagnosis is of great importance during pregnancy because many other diseases can mimic pregnancy reaction. In this patient, the intracranial hypertension caused by recurrent cerebellar hemangioblastomas was misdiagnosed as pregnancy reaction and it was suggested that the change of hormones, neuroendocrine, and cardiovascular function promoted the recurrence of cerebellar hemangioblastomas.
妊娠合并小脑血管母细胞瘤罕见，但妊娠合并复发性小脑血管母细胞瘤更为罕见。并且妊娠期间合并其他疾病通常会因妊娠反应而导致误诊。一名 29 岁女性，在妊娠第 8 周时出现恶心、呕吐和阵发性枕后头痛，在当地医院多次就诊时被误诊为妊娠反应，未进行任何特殊治疗。患者在 14 年前被诊断为小脑血管母细胞瘤，手术后定期复查，无复发。妊娠 15 周时，患者病情加重，入住我院。脑部磁共振成像显示小脑有病变。考虑为小脑血管母细胞瘤，最终通过术后病理检查证实。在临床实践中，由于许多其他疾病可模拟妊娠反应，因此在妊娠期间进行鉴别诊断非常重要。在本例患者中，由复发性小脑血管母细胞瘤引起的颅内压增高被误诊为妊娠反应，提示激素、神经内分泌和心血管功能的变化促进了小脑血管母细胞瘤的复发。
