三联苯壁式甘脲三聚体：合成与识别特性
Triptycene Walled Glycoluril Trimer: Synthesis and Recognition Properties.
作者信息
Ndendjio Sandra Zebaze, Liu Wenjin, Yvanez Nicolas, Meng Zihui, Zavalij Peter Y, Isaacs Lyle
机构信息
Department of Chemistry and Biochemistry, University of Maryland, College Park, Maryland 20742, USA.
School of Chemistry and Chemical Engineering, Beijing Institute of Technology, 5 South Zhongguancun Street, Beijing 100081, P. R. China.
出版信息
New J Chem. 2020;44(2):338-345. doi: 10.1039/c9nj05336k. Epub 2019 Nov 28.
Abstract
We report the synthesis of a new acyclic CB[n]-type host (1) that features a central glycoluril trimer capped by triptycene sidewalls. Host 1 has good solubility in water (≈ 3 mM) and does not undergo strong self-association (K = 480 M). We probed the geometry of the complexes by analyzing the complexation induced changes in the H NMR spectra and measured the complexation thermodynamics by isothermal titration calorimetry. The conformation of 1 and its packing in the solid state was revealed by single crystal x-ray diffraction measurements.
摘要
我们报道了一种新型无环CB[n]型主体（1）的合成，该主体具有由三蝶烯侧壁封端的中心甘脲三聚体。主体1在水中具有良好的溶解性（约3 mM），且不会发生强烈的自缔合（K = 480 M）。我们通过分析1H NMR光谱中络合诱导的变化来探究络合物的几何结构，并通过等温滴定量热法测量络合热力学。通过单晶X射线衍射测量揭示了1在固态下的构象及其堆积情况。
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