• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

骆驼奶对C57BL/6 J小鼠辐射诱导的肠道损伤的抗氧化和免疫保护作用

Anti-Oxidative and Immuno-Protective Effect of Camel Milk on Radiation-Induced Intestinal Injury in C57BL/6 J Mice.

作者信息

Chen Yu-Zhong, Li Chao, Gu Jia, Lv Si-Chen, Song Jia-Ying, Tang Zhi-Bing, Duan Guang-Xin, Qin Li-Qiang, Zhao Lin, Xu Jia-Ying

机构信息

State Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection, Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Soochow University, Suzhou, China.

Suzhou Kowloon Hospital, Shanghai Jiaotong University School of Medicine, Suzhou, China.

出版信息

Dose Response. 2021 Mar 30;19(1):15593258211003798. doi: 10.1177/15593258211003798. eCollection 2021 Jan-Mar.

DOI:10.1177/15593258211003798
PMID:33867894
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8020251/
Abstract

PURPOSE

The main objective is to investigate the protective effect of camel milk (CM) on radiation-induced intestinal injury.

METHODS

The C57BL/6 J mice in 2 experiments were assigned into control group (Con), irradiation group (IR), and CM+irradiation group (CM+IR). After receiving the CM via gavage for 14 days, the mice in the first experiment were exposed to 6 Gy X-ray whole body irradiation, and survival rate was compared among the groups. Mice in the second experiment were exposed to 4 Gy irradiation and sacrificed at day 7. The small intestines were collected to examine the histopathological changes and to determine the anti-oxidative index and HMGB1/TLR4 inflammatory pathway. Fasting blood was used to measure serum pro-inflammatory factors.

RESULTS

Compared with the IR group, the survival time was prolonged, and survival rate was increased in the CM+IR group. CM increased levels of SOD and GSH and decreased MDA in the jejunum. Furthermore, intestinal protein expression of HMGB1/TLR4 pathway (TLR4, NF-κB, and HMGB1) was up-regulated by CM intervention. CM decreased the serum levels of TNF-α and IL-1β and increased IL-10 level.

CONCLUSIONS

CM extended the survival time and had a protective effect against radiation-induced jejunum injury by regulation of antioxidant capacity and HMGB1/TLR4/NF-κB/MyD88 inflammatory signaling pathway.

摘要

目的

主要目的是研究骆驼奶（CM）对辐射诱导的肠道损伤的保护作用。

方法

2个实验中的C57BL/6 J小鼠被分为对照组（Con）、照射组（IR）和CM +照射组（CM + IR）。通过灌胃给予CM 14天后，第一个实验中的小鼠接受6 Gy X射线全身照射，比较各组的存活率。第二个实验中的小鼠接受4 Gy照射，并在第7天处死。收集小肠以检查组织病理学变化，并测定抗氧化指标和HMGB1/TLR4炎症通路。空腹血液用于测量血清促炎因子。

结果

与IR组相比，CM + IR组的存活时间延长，存活率提高。CM增加了空肠中SOD和GSH的水平，并降低了MDA水平。此外，CM干预上调了HMGB1/TLR4通路（TLR4、NF-κB和HMGB1）的肠道蛋白表达。CM降低了血清TNF-α和IL-1β水平，并提高了IL-10水平。

结论

CM通过调节抗氧化能力和HMGB1/TLR4/NF-κB/MyD88炎症信号通路延长了存活时间，并对辐射诱导的空肠损伤具有保护作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d3f/8020251/d0f4dcbcd817/10.1177_15593258211003798-fig7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d3f/8020251/543f891ac565/10.1177_15593258211003798-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d3f/8020251/4dcf184a4bad/10.1177_15593258211003798-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d3f/8020251/04bd30c4d7f1/10.1177_15593258211003798-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d3f/8020251/7f55fc626889/10.1177_15593258211003798-fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d3f/8020251/8fc879838a91/10.1177_15593258211003798-fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d3f/8020251/a030aaeea56f/10.1177_15593258211003798-fig6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d3f/8020251/d0f4dcbcd817/10.1177_15593258211003798-fig7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d3f/8020251/543f891ac565/10.1177_15593258211003798-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d3f/8020251/4dcf184a4bad/10.1177_15593258211003798-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d3f/8020251/04bd30c4d7f1/10.1177_15593258211003798-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d3f/8020251/7f55fc626889/10.1177_15593258211003798-fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d3f/8020251/8fc879838a91/10.1177_15593258211003798-fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d3f/8020251/a030aaeea56f/10.1177_15593258211003798-fig6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d3f/8020251/d0f4dcbcd817/10.1177_15593258211003798-fig7.jpg

相似文献

1
Anti-Oxidative and Immuno-Protective Effect of Camel Milk on Radiation-Induced Intestinal Injury in C57BL/6 J Mice.骆驼奶对C57BL/6 J小鼠辐射诱导的肠道损伤的抗氧化和免疫保护作用
Dose Response. 2021 Mar 30;19(1):15593258211003798. doi: 10.1177/15593258211003798. eCollection 2021 Jan-Mar.
2
Effect of Clostridium perfringens type C on TLR4/MyD88/NF-κB signaling pathway in piglet small intestines.C 型产气荚膜梭菌对仔猪小肠 TLR4/MyD88/NF-κB 信号通路的影响。
Microb Pathog. 2019 Oct;135:103567. doi: 10.1016/j.micpath.2019.103567. Epub 2019 Jun 1.
3
Effects of lactoferrin on X-ray-induced intestinal injury in Balb/C mice.乳铁蛋白对Balb/C小鼠X射线诱导的肠道损伤的影响。
Appl Radiat Isot. 2019 Apr;146:72-77. doi: 10.1016/j.apradiso.2019.01.014. Epub 2019 Jan 28.
4
Glycyrrhizin Ameliorates Radiation Enteritis in Mice Accompanied by the Regulation of the HMGB1/TLR4 Pathway.甘草酸通过调节HMGB1/TLR4通路改善小鼠放射性肠炎。
Evid Based Complement Alternat Med. 2020 May 31;2020:8653783. doi: 10.1155/2020/8653783. eCollection 2020.
5
The protective effect of dexmedetomidine on LPS-induced acute lung injury through the HMGB1-mediated TLR4/NF-κB and PI3K/Akt/mTOR pathways.右美托咪定通过 HMGB1 介导体 TLR4/NF-κB 和 PI3K/Akt/mTOR 通路对 LPS 诱导的急性肺损伤的保护作用。
Mol Immunol. 2018 Feb;94:7-17. doi: 10.1016/j.molimm.2017.12.008. Epub 2017 Dec 11.
6
TLR4-HMGB1-, MyD88- and TRIF-dependent signaling in mouse intestinal ischemia/reperfusion injury.TLR4-HMGB1、MyD88和TRIF依赖性信号通路在小鼠肠道缺血/再灌注损伤中的作用
World J Gastroenterol. 2015 Jul 21;21(27):8314-25. doi: 10.3748/wjg.v21.i27.8314.
7
Dexmedetomidine Resists Intestinal Ischemia-Reperfusion Injury by Inhibiting TLR4/MyD88/NF-κB Signaling.右美托咪定通过抑制 TLR4/MyD88/NF-κB 信号通路抵抗肠缺血再灌注损伤。
J Surg Res. 2021 Apr;260:350-358. doi: 10.1016/j.jss.2020.11.041. Epub 2020 Dec 28.
8
Glutamine decreases intestinal mucosal injury in a rat model of intestinal ischemia-reperfusion by downregulating HMGB1 and inflammatory cytokine expression.谷氨酰胺通过下调高迁移率族蛋白B1（HMGB1）和炎性细胞因子的表达，减轻大鼠肠缺血再灌注模型中的肠黏膜损伤。
Exp Ther Med. 2016 Sep;12(3):1367-1372. doi: 10.3892/etm.2016.3468. Epub 2016 Jun 17.
9
Camel Milk Ameliorates 5-Fluorouracil-Induced Renal Injury in Rats: Targeting MAPKs, NF-κB and PI3K/Akt/eNOS Pathways.骆驼奶改善5-氟尿嘧啶诱导的大鼠肾损伤：靶向丝裂原活化蛋白激酶、核因子κB和磷脂酰肌醇-3激酶/蛋白激酶B/内皮型一氧化氮合酶信号通路
Cell Physiol Biochem. 2018;46(4):1628-1642. doi: 10.1159/000489210. Epub 2018 Apr 20.
10
The protective effect of formononetin on cognitive impairment in streptozotocin (STZ)-induced diabetic mice.芒柄花素对链脲佐菌素（STZ）诱导的糖尿病小鼠认知障碍的保护作用。
Biomed Pharmacother. 2018 Oct;106:1250-1257. doi: 10.1016/j.biopha.2018.07.063. Epub 2018 Jul 20.

引用本文的文献

1
Non-Bovine Milk as Functional Foods with Focus on Their Antioxidant and Anti-Inflammatory Bioactivities.非牛乳作为功能性食品，重点关注其抗氧化和抗炎生物活性。
Antioxidants (Basel). 2025 Jun 27;14(7):801. doi: 10.3390/antiox14070801.
2
Exploring the anti-diabetic properties of camel milk: effects on blood glucose, antioxidant defense, and organ histo-morphological features in rabbits.探索骆驼奶的抗糖尿病特性：对兔子血糖、抗氧化防御及器官组织形态学特征的影响
J Mol Histol. 2025 Feb 19;56(2):92. doi: 10.1007/s10735-025-10371-0.
3
Camel milk inhibits pulmonary oxidative stress and inflammation in a rat model of COPD induced by cigarette smoke exposure.

本文引用的文献

1
At What Dose Can Total Body and Whole Abdominal Irradiation Cause Lethal Intestinal Injury Among C57BL/6J Mice?全身和全腹照射对C57BL/6J小鼠造成致死性肠道损伤的剂量是多少？
Dose Response. 2020 Sep 10;18(3):1559325820956783. doi: 10.1177/1559325820956783. eCollection 2020 Jul-Sep.
2
Correlation between elevated inflammatory cytokines of spleen and spleen index in acute spinal cord injury.脾脏炎症细胞因子升高与急性脊髓损伤的脾脏指数相关。
J Neuroimmunol. 2020 Jul 15;344:577264. doi: 10.1016/j.jneuroim.2020.577264. Epub 2020 May 16.
3
Determination of Lactoferrin in Camel Milk by Ultrahigh-Performance Liquid Chromatography-Tandem Mass Spectrometry Using an Isotope-Labeled Winged Peptide as Internal Standard.
骆驼奶可抑制香烟烟雾暴露诱导的慢性阻塞性肺疾病大鼠模型中的肺部氧化应激和炎症反应。
Heliyon. 2024 Oct 16;10(20):e39416. doi: 10.1016/j.heliyon.2024.e39416. eCollection 2024 Oct 30.
4
Bactrian Camel Milk: Chemical Composition, Bioactivities, Processing Techniques, and Economic Potential in China.双峰驼乳：在中国的化学组成、生物活性、加工技术和经济潜力。
Molecules. 2024 Oct 2;29(19):4680. doi: 10.3390/molecules29194680.
5
WZ1 Inhibits the Inflammatory Injury of Mouse Jejunum Caused by Enterotoxigenic K88 by Regulating the TLR4/NF-κB/MyD88 Inflammatory Pathway and Gut Microbiota.WZ1通过调节TLR4/NF-κB/MyD88炎症通路和肠道微生物群抑制产肠毒素K88引起的小鼠空肠炎症损伤。
Microorganisms. 2023 Mar 3;11(3):657. doi: 10.3390/microorganisms11030657.
6
The Antioxidant, Anti-Inflammatory and Immunomodulatory Effects of Camel Milk.骆驼奶的抗氧化、抗炎和免疫调节作用。
Front Immunol. 2022 Apr 12;13:855342. doi: 10.3389/fimmu.2022.855342. eCollection 2022.
采用同位素标记的 Winged Peptide 作为内标，通过超高效液相色谱-串联质谱法测定驼乳中的乳铁蛋白。
Molecules. 2019 Nov 19;24(22):4199. doi: 10.3390/molecules24224199.
4
Camel milk exosomes modulate cyclophosphamide-induced oxidative stress and immuno-toxicity in rats.骆驼奶外泌体调节环磷酰胺诱导的大鼠氧化应激和免疫毒性。
Food Funct. 2019 Nov 1;10(11):7523-7532. doi: 10.1039/c9fo01914f.
5
Effect of Taurine on Thymus Differentiation of Dex-Induced Immunosuppressive Mice.牛磺酸对地塞米松诱导免疫抑制小鼠胸腺分化的影响。
Adv Exp Med Biol. 2019;1155:381-390. doi: 10.1007/978-981-13-8023-5_36.
6
TLR4 Agonist Monophosphoryl Lipid A Alleviated Radiation-Induced Intestinal Injury.TLR4 激动剂单磷酰脂质 A 缓解放射性肠损伤。
J Immunol Res. 2019 Jun 3;2019:2121095. doi: 10.1155/2019/2121095. eCollection 2019.
7
Effects of lactoferrin on X-ray-induced intestinal injury in Balb/C mice.乳铁蛋白对Balb/C小鼠X射线诱导的肠道损伤的影响。
Appl Radiat Isot. 2019 Apr;146:72-77. doi: 10.1016/j.apradiso.2019.01.014. Epub 2019 Jan 28.
8
The protective effects of XH-105 against radiation-induced intestinal injury.XH-105 对辐射诱导的肠道损伤的保护作用。
J Cell Mol Med. 2019 Mar;23(3):2238-2247. doi: 10.1111/jcmm.14159. Epub 2019 Jan 20.
9
Amelioration of whole abdominal irradiation-induced intestinal injury in mice with 3,3'-Diindolylmethane (DIM).3,3'-二吲哚甲烷（DIM）改善小鼠全腹部照射诱导的肠道损伤。
Free Radic Biol Med. 2019 Jan;130:244-255. doi: 10.1016/j.freeradbiomed.2018.10.410. Epub 2018 Oct 21.
10
Protective effect of polydatin on radiation-induced injury of intestinal epithelial and endothelial cells.虎杖苷对辐射诱导的肠上皮细胞和内皮细胞损伤的保护作用。
Biosci Rep. 2018 Nov 13;38(6). doi: 10.1042/BSR20180868. Print 2018 Dec 21.