Selnes O A, Carson K, Rovner B, Gordon B
Department of Neurology, Johns Hopkins University, Baltimore, MD.
Neurology. 1988 Jul;38(7):1053-6. doi: 10.1212/wnl.38.7.1053.
Disproportionate involvement of language has been claimed to be a distinguishing feature of Alzheimer's disease (AD) with onset before age 65. We tested this hypothesis in a group of 133 patients with possible AD by NINCDS criteria. Sixty-one had onset of symptoms prior to age 65; the remaining 72, at 65 or later. The two groups were well matched on overall dementia severity as measured by the Mini-Mental State Exam. Using standardized tests, we did not find any significant differences in the severity of language dysfunction between the two groups, particularly after controlling for greater attention/concentration deficits in the early-onset group. Previous reports of differences in language dysfunction between early- and late-onset AD may have been due to small sample sizes and nonstandardized testing.
有人声称，语言功能的不成比例受累是65岁之前发病的阿尔茨海默病（AD）的一个显著特征。我们通过NINCDS标准，对一组133例可能患有AD的患者进行了这一假设的检验。其中61例在65岁之前出现症状；其余72例在65岁及以后出现症状。通过简易精神状态检查评估，两组在总体痴呆严重程度方面匹配良好。使用标准化测试，我们未发现两组之间语言功能障碍严重程度有任何显著差异，尤其是在控制了早发型组中更严重的注意力/集中力缺陷之后。先前关于早发型和晚发型AD语言功能障碍差异的报道可能是由于样本量小和测试未标准化所致。
