Linxweiler Maximilian, Wang Jingming, Morris Luc G T
Department of Otorhinolaryngology, Head and Neck Surgery, Saarland University Medical Center, Homburg/Saar, Germany.
Immunogenomics and Precision Oncology Platform, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Oncotarget. 2021 Mar 30;12(7):592-595. doi: 10.18632/oncotarget.27900.
Pleomorphic adenoma (PA), the most common salivary gland tumor, is a benign tumor that carries a risk of malignant transformation to various histologies of carcinoma ex pleomorphic adenoma (CA exPA). Recently, genomic analyses have provided deeper insights into the molecular biology of salivary gland cancers. However, the molecular processes that underlie the progression from PA to CA exPA are largely unknown. In this study, we used RNAseq data from CA ex PA of myoepithelial ( = 24) or salivary duct histology ( = 6), myoepithelial carcinoma ( = 16) and salivary duct carcinoma ( = 10), and compared their constituent immune tumor microenvironments. We found that increasing levels of immune infiltration and activation were associated with a generally lower probability of cancer developing ex-PA, suggesting that immune surveillance may constrain the malignant transformation of benign salivary tumors. More immunologically infiltrated tumors were more likely to have developed . Taken together, these data suggest a role for tumor escape from immune surveillance in the development of CA exPA. The immune-cold microenvironments of CA ex PA tumors may in part explain their more aggressive clinical behavior.
多形性腺瘤（PA）是最常见的唾液腺肿瘤，是一种良性肿瘤，但有恶变为多形性腺瘤癌变（CA exPA）各种组织学类型的风险。最近，基因组分析为唾液腺癌的分子生物学提供了更深入的见解。然而，PA进展为CA exPA的分子过程在很大程度上尚不清楚。在本研究中，我们使用了来自肌上皮组织学（n = 24）或唾液管组织学（n = 6）的CA ex PA、肌上皮癌（n = 16）和唾液管癌（n = 10）的RNAseq数据，并比较了它们组成的免疫肿瘤微环境。我们发现，免疫浸润和激活水平的增加与PA发生癌变的总体可能性降低相关，这表明免疫监视可能会限制良性唾液腺肿瘤的恶性转化。免疫浸润程度更高的肿瘤更有可能已经发生了癌变。综上所述，这些数据表明肿瘤逃避免疫监视在CA exPA的发生发展中起作用。CA ex PA肿瘤的免疫冷微环境可能部分解释了它们更具侵袭性的临床行为。
